Cell Ontology

Last uploaded: February 1, 2021
Preferred Name

cerebral cortex

Synonyms

cortex of cerebral hemisphere

pallium of the brain

cortical plate (areas)

cortex cerebralis

cortex cerebri

brain cortex

cortical plate (CTXpl)

Definitions

The thin layer of gray matter on the surface of the cerebral hemisphere that develops from the telencephalon. It consists of the neocortex (6 layered cortex or isocortex), the hippocampal formation and the olfactory cortex.

ID

http://purl.obolibrary.org/obo/UBERON_0000956

contributes to morphology of

http://purl.obolibrary.org/obo/UBERON_0001893

database_cross_reference

DHBA:10159

VHOG:0000722

MA:0000185

UMLS:C0007776

GAID:629

MESH:A08.186.211.730.885.213

BM:Tel-Cx

EV:0100166

EMAPA:17544

BIRNLEX:1494

MBA:688

FMA:61830

EHDAA:5464

BAMS:Cerebral_cortex

CALOHA:TS-0091

EHDAA2:0000234

PBA:128011354

BAMS:CTX

MIAA:0000108

BAMS:C

NCIT:C12443

HBA:4008

BTO:0000233

BAMS:Cx

http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=39

MAT:0000108

EFO:0000328

http://en.wikipedia.org/wiki/Cerebral_cortex

http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=39

http://www.snomedbrowser.com/Codes/Details/362880003

http://linkedlifedata.com/resource/umls/id/C0007776

definition

The thin layer of gray matter on the surface of the cerebral hemisphere that develops from the telencephalon. It consists of the neocortex (6 layered cortex or isocortex), the hippocampal formation and the olfactory cortex.

depicted_by

http://upload.wikimedia.org/wikipedia/commons/7/7b/Cerebral_Cortex_location.jpg

http://upload.wikimedia.org/wikipedia/commons/9/9a/Brainmaps-macaque-hippocampus.jpg

has developmental contribution from

http://purl.obolibrary.org/obo/UBERON_0005343

http://purl.obolibrary.org/obo/UBERON_0004035

has_exact_synonym

cortex of cerebral hemisphere

has_obo_namespace

uberon

has_related_synonym

pallium of the brain

cortical plate (areas)

cortex cerebralis

cortex cerebri

brain cortex

cortical plate (CTXpl)

IAO_0000232

We follow NIFSTD in defining cerebral cortex and including both neocortex and hippocampal formation (DG+hippocampus).

id

UBERON:0000956

in_subset

http://purl.obolibrary.org/obo/uberon/core#uberon_slim

http://purl.obolibrary.org/obo/uberon/core#pheno_slim

http://purl.obolibrary.org/obo/uberon/core#efo_slim

label

cerebral cortex

notation

UBERON:0000956

part_of

http://purl.obolibrary.org/obo/UBERON_0005401

http://purl.obolibrary.org/obo/UBERON_0000203

prefLabel

cerebral cortex

RO_0002175

http://purl.obolibrary.org/obo/NCBITaxon_117569

treeView

http://purl.obolibrary.org/obo/UBERON_0005401

http://purl.obolibrary.org/obo/UBERON_0000203

UBPROP_0000001

The cerebral cortex is a structure within the brain that plays a key role in memory, attention, perceptual awareness, thought, language, and consciousness. It constitutes the outermost layer of the cerebrum. In preserved brains, it has a grey color, hence the name 'grey matter'. Grey matter is formed by neurons and their unmyelinated fibers, whereas the white matter below the grey matter of the cortex is formed predominantly by myelinated axons interconnecting different regions of the central nervous system. The human cerebral cortex is 2-4 mm (0.08-0.16 inches) thick. The surface of the cerebral cortex is folded in large mammals, such that more than two-thirds of the cortical surface is buried in the grooves, called 'sulci. ' The phylogenetically most recent part of the cerebral cortex, the neocortex, also called isocortex, is differentiated into six horizontal layers; the more ancient part of the cerebral cortex, the hippocampus (also called archicortex), has at most three cellular layers, and is divided into subfields. Relative variations in thickness or cell type (among other parameters) allow us to distinguish between different neocortical architectonic fields. The geometry of at least some of these fields seems to be related to the anatomy of the cortical folds, and, for example, layers in the upper part of the cortical ridges seem to be more clearly differentiated than in its deeper parts. [WP,unvetted][Wikipedia:Cerebral_cortex].

UBPROP_0000003

Migration of neurons from the basal or striatal portions of the anterior part of the neural tube occurs to varying degrees in different vertebrate classes, but a true cerebral cortex is generally acknowledged to have made its first appearance in reptiles. The definition can be unambiguous, since 'cortex' simply implies the existence of a surface neuronal layer with an overlying 'zonal lamina' or 'molecular' layer containing dendrites and axons, which is separated from the underlying basal 'matrix' by white matter. Although reptilian cerebral cortex does indeed fulfill these conditions in certain locations, the separation from striatal structures is often indistinct, so that it may even be argued that some primitive dipnoans possess a pallium or cortex. Nevertheless, an extensive laminated layer separated by underlying white matter is well represented only in reptiles and mammals.[well established][VHOG]

UBPROP_0000008

hagfishes have independently evolved a highly laminated cerebral cortex, comparable in many ways to the cerebral cortex of mammals [http://icb.oxfordjournals.org/content/42/4/743]

subClassOf

http://purl.obolibrary.org/obo/UBERON_0016548

http://purl.obolibrary.org/obo/UBERON_0011215

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Internal mappings

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http://purl.obolibrary.org/obo/UBERON_0000956 Experimental Factor Ontology LOOM
http://purl.obolibrary.org/obo/UBERON_0000956 Experimental Factor Ontology SAME_URI
http://lod.nal.usda.gov/nalt/24050 National Agricultural Library Thesaurus LOOM
http://www.yso.fi/onto/yso/p7039 Agriculture and Forestry Ontology LOOM
http://id.agrisemantics.org/gacs/C24636 Global Agricultural Concept Scheme LOOM

Interportal mappings

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External mappings

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