Category=family. Classification based on GRAFS system. [PMID:12761335]

Category=family. Classification based on GRAFS system. [PMID:12761335]

IUPHAR:GPCRListForward?class=A

PIRSF:PIRSF800006

A G-protein coupled receptor that contains the 7 transmembrane receptor (rhodopsin family) domain (Pfam:PF00001), which includes 7 transmembrane helices (TMI-TM7) with 3 intracellular loops (IL1-IL3) and 3 extracellular loops (EL1-EL3) between the helices. The amino-terminal region is extracellular and the carboxyl-terminal region is intracellular. Rhodopsin-like G-protein coupled receptors (GPCRs) are unique among the several classes of GPCRs in that most have a very short amino-terminal segment and several characteristic sequence motifs, particularly NSxxNPxxY in TM7 and D/E-R-Y/F between TM3 and loop IL2. Most bind their ligands within a cavity between the TM regions.

PR:000001094

class 1 G-protein coupled receptor

fam:rhodopsin

class A G-protein coupled receptor

protein

PR:000001094

rhodopsin-like G-protein coupled receptor