Cell Ontology (CL)
OWL
Last submission date April 11, 2025
ID http://purl.obolibrary.org/obo/GO_1904602
http://purl.obolibrary.org/obo/GO_1904602
https://agroportal.lirmm.fr/ontologies/CL/GO_1904602
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Preferred name

serotonin-activated cation-selective channel complex

Synonyms
5-HT-3 receptor complex 5-HT3 receptor complex 5-hydroxytryptamine receptor 3 complex 5HT3 receptor complex serotonin receptor complex
Definitions
An example of this is HTR3A in human (P46098) in PMID:16116092 (inferred from direct assay). A protein complex which is capable of serotonin-activated cation-selective channel activity. Mainly found in pre- and postsynaptic membranes of the brain and gastrointestinal tract. Depending on its location it transports Ca2+, Mg2+, Na+ or K+. It is always a pentamer, containing at least the 5HT3A subunit forming 5HT3A homopentamers or 5HT3A/B heteropentamers. In human, 5HT3A/C, A/D and A/E heteropentamers also exist.
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