Cell Ontology (CL)
OWL
Last submission date April 11, 2025
ID http://purl.obolibrary.org/obo/CL_4030033
http://purl.obolibrary.org/obo/CL_4030033
https://agroportal.lirmm.fr/ontologies/CL/CL_4030033
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Preferred name

valve endothelial cell

Synonyms
VEC valvular endothelial cell
Definitions
At least in some mammalian species, a valve endothelial cell expresses CD31. Valve endothelial cells can undergo an endothelial to mesenchymal transition to acquire a fibroblast or myofibroblast phenotype that leads to changes in the microenvironmental signals and facilitates tissue regeneration. An endothelial cell that lines a surface of a cardiac valve leaflet. Along with valve interstitial cells, a valve endothelial cell maintains tissue homeostasis for the function of cardiac valves through secreting biochemical signals, matrix proteins and matrix remodeling enzymes.
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