Vertebrate Trait Ontology (VT)
OWL
Last submission date February 12, 2025
ID http://purl.obolibrary.org/obo/VT_0008197
http://purl.obolibrary.org/obo/VT_0008197
https://agroportal.lirmm.fr/ontologies/VT/VT_0008197
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Preferred name

follicular dendritic cell physiology trait

Definitions
Annotations to this cell type have been erroneously made to dendritic cell morphology trait. These are unrelated to the dendritic cell associated with T cells. Follicular dendritic cells have Fc receptors and C3b receptors, but unlike other dendritic cells, they do not process or present antigen in a way that allows recognition by T cells. Instead, they hold antigen in the form of immune complexes on their surfaces for long periods and can present antigen to B cells during an immune response. They are not derived from the hematopoietic lineage. Due to its unique lineage and distinct function (B cell vs. T cell presentation), this is NOT a type of dendritic cell. Any measurable or observable characteristic related to the function of or processes in a cell with extensive dendritic processes found in the B cell areas (primary follicles and germinal centers) of lymphoid tissue; follicular dendritic cells have Fc receptors and C3b receptors, and hold antigen in the form of immune complexes on their surfaces for long periods and can present antigen to B cells during an immune response.
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