Protein Ontology (PR)
OWL
Last submission date February 17, 2024
ID http://purl.obolibrary.org/obo/PR_000001030
http://purl.obolibrary.org/obo/PR_000001030
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Preferred name

erm protein

Definitions

A protein that contain 3 domains, an N-terminal globular domain, an extended alpha-helical domain, and a charged C-terminal domain. Ezrin, radixin and merlin also contain a polyproline region between the helical and C-terminal domains. The N-terminal domain is highly conserved, and is also found in merlin, band 4.1 proteins and members of the band 4.1 superfamily. ERM proteins are involved in crosslinking actin filaments with plasma membranes.

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