PR | Classes | AgroPortal

ID	http://purl.obolibrary.org/obo/PR_000001006 http://purl.obolibrary.org/obo/PR_000001006 https://agroportal.lirmm.fr/ontologies/PR/PR_000001006 Loading
Preferred name	receptor-type tyrosine-protein phosphatase C
Synonyms	L-CA PTPRC leukocyte common antigen ly-5 lymphocyte antigen 5 T200 CD45 See more See less
Definitions	Category=gene. Requested by=CL. A protein that is a translation product of the human PTPRC gene or a 1:1 ortholog thereof. It is composed of an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic protein-tyrosine phosphatase domains. Contains 1 to 3 copies of the Fibronectin type III domain (Pfam:PF00041) followed by two copies of the Protein-tyrosine phosphatase (Pfam:PF00102) domain. Receptor-type tyrosine-protein phosphatase C (CD45) regulates signal transduction and lymphocyte activation by specific association with receptor molecules on T and B cells. Multiple isoforms of CD45 (180-235 kDa) can be generated asa result of alternative splicing of three variable exons 4(A), 5(B) and 6(C), encoding sequences at the N-terminal extracellular domain of the molecule.

rdfs:comment	Category=gene. Requested by=CL.
rdf:type	http://www.w3.org/2002/07/owl#Class Loading
rdfs:subClassOf	http://purl.obolibrary.org/obo/PR_000000001 Loading
rdfs:label	receptor-type tyrosine-protein phosphatase C
skos:notation	PR:000001006
obo_purl:IAO_0000115	A protein that is a translation product of the human PTPRC gene or a 1:1 ortholog thereof. It is composed of an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic protein-tyrosine phosphatase domains. Contains 1 to 3 copies of the Fibronectin type III domain (Pfam:PF00041) followed by two copies of the Protein-tyrosine phosphatase (Pfam:PF00102) domain. Receptor-type tyrosine-protein phosphatase C (CD45) regulates signal transduction and lymphocyte activation by specific association with receptor molecules on T and B cells. Multiple isoforms of CD45 (180-235 kDa) can be generated asa result of alternative splicing of three variable exons 4(A), 5(B) and 6(C), encoding sequences at the N-terminal extracellular domain of the molecule.
oboinowl_gen:hasExactSynonym	L-CA PTPRC leukocyte common antigen ly-5 lymphocyte antigen 5
oboinowl_gen:hasDbXref	IUPHARobj:1852 PIRSF:PIRSF002004
oboinowl_gen:hasOBONamespace	protein
oboinowl_gen:id	PR:000001006
oboinowl_gen:hasBroadSynonym	T200
oboinowl_gen:hasRelatedSynonym	CD45

Subject	Author	Type	Created
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