@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> . @prefix obo_purl: <http://purl.obolibrary.org/obo/> . @prefix owl: <http://www.w3.org/2002/07/owl#> . @prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> . @prefix skos: <http://www.w3.org/2004/02/skos/core#> . @prefix metadata_def: <http://data.bioontology.org/metadata/def/> . @prefix ns0: <Requested\u0020by\u0020Stephen\u0020Grossmann\u0020Dec\u00202004.\u0020Changed\u0020relationship\u0020from\u0020has_part\u0020SO:0000235\u0020TF_binding\u0020site\u0020to\u0020TF_binding_site\u0020is\u0020part_of\u0020SO:0000727\u0020CRM\u0020in\u0020response\u0020to\u0020requests\u0020from\u0020GREEKC\u0020initiative\u0020in\u0020Aug\u00202020.\u0020Removed\u00203'\u0020from\u0020definition\u0020because\u00205'\u0020UTRs\u0020are\u0020included\u0020as\u0020well,\u0020notified\u0020by\u0020Colin\u0020Logie\u0020of\u0020GREEKC.\u0020Nov\u00209\u00202020.\u0020DS\u0020Updated\u0020name\u0020from\u0020'CRM'\u0020to\u0020'cis_regulatory_module'\u0020on\u002008\u0020Feb\u00202021.\u0020See\u0020GitHub\u0020Issue\u0020#526.\u0020DS\u0020Added\u0020final\u0020sentence\u0020to\u0020definition\u0020as\u0020part\u0020of\u0020GREEKC\u0020Feb\u002016,\u00202021.\u0020See\u0020GitHub\u0020Issue\u0020#> . @prefix oboinowl_gen: <http://www.geneontology.org/formats/oboInOwl#> . @prefix ns1: <http://purl.obolibrary.org/obo/so#> . @prefix ns2: <http://data.bioontology.org/metadata/obo/> . @prefix metadata: <http://data.bioontology.org/metadata/> . obo_purl:SO_0000037 rdfs:subClassOf obo_purl:SO_0000727 . obo_purl:SO_0000165 rdfs:subClassOf obo_purl:SO_0000727 . obo_purl:SO_0000235 ns2:part_of obo_purl:SO_0000727 ; metadata:treeView obo_purl:SO_0000727 . obo_purl:SO_0000625 rdfs:subClassOf obo_purl:SO_0000727 . obo_purl:SO_0000627 rdfs:subClassOf obo_purl:SO_0000727 . obo_purl:SO_0000727 metadata_def:mappingLoom "cisregulatorymodule" ; metadata_def:mappingSameURI obo_purl:SO_0000727 ; metadata_def:prefLabel "cis_regulatory_module" ; obo_purl:IAO_0000115 "A regulatory region where transcription factor binding sites are clustered to regulate various aspects of transcription activities. (CRMs can be located a few kb to hundreds of kb upstream of the core promoter, in the coding sequence, within introns, or in the untranslated regions (UTR) sequences, and even on a different chromosome). A single gene can be regulated by multiple CRMs to give precise control of its spatial and temporal expression. CRMs function as nodes in large, intertwined regulatory network. CRM DNA accessibility is subject to regulation by dbTFs and transcription co-TFs." ; oboinowl_gen:hasExactSynonym "CRM", "TF module", "cis regulatory module", "transcription factor module" ; oboinowl_gen:hasOBONamespace "sequence" ; oboinowl_gen:id "SO:0000727" ; oboinowl_gen:inSubset ns1:SOFA ; a owl:Class ; rdfs:comment "Requested by Stephen Grossmann Dec 2004. Changed relationship from has_part SO:0000235 TF_binding site to TF_binding_site is part_of SO:0000727 CRM in response to requests from GREEKC initiative in Aug 2020. Removed 3' from definition because 5' UTRs are included as well, notified by Colin Logie of GREEKC. Nov 9 2020. DS Updated name from 'CRM' to 'cis_regulatory_module' on 08 Feb 2021. See GitHub Issue #526. DS Added final sentence to definition as part of GREEKC Feb 16, 2021. See GitHub Issue #534." ; rdfs:label "cis_regulatory_module" ; rdfs:subClassOf obo_purl:SO_0001055 ; skos:notation "SO:0000727" . obo_purl:SO_0002308 rdfs:subClassOf obo_purl:SO_0000727 .