<?xml version="1.0" encoding="UTF-8"?> <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:obo_purl="http://purl.obolibrary.org/obo/" xmlns:owl="http://www.w3.org/2002/07/owl#" xmlns:rdfs="http://www.w3.org/2000/01/rdf-schema#" xmlns:skos="http://www.w3.org/2004/02/skos/core#" xmlns:oboinowl_gen="http://www.geneontology.org/formats/oboInOwl#" xmlns:metadata_def="http://data.bioontology.org/metadata/def/"> <owl:Class rdf:about="http://purl.obolibrary.org/obo/PR_000001006"> <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PR_000000001"/> <rdfs:label>receptor-type tyrosine-protein phosphatase C</rdfs:label> <rdfs:comment>Category=gene. Requested by=CL.</rdfs:comment> <skos:notation>PR:000001006</skos:notation> <obo_purl:IAO_0000115>A protein that is a translation product of the human PTPRC gene or a 1:1 ortholog thereof. It is composed of an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic protein-tyrosine phosphatase domains. Contains 1 to 3 copies of the Fibronectin type III domain (Pfam:PF00041) followed by two copies of the Protein-tyrosine phosphatase (Pfam:PF00102) domain. Receptor-type tyrosine-protein phosphatase C (CD45) regulates signal transduction and lymphocyte activation by specific association with receptor molecules on T and B cells. Multiple isoforms of CD45 (180-235 kDa) can be generated asa result of alternative splicing of three variable exons 4(A), 5(B) and 6(C), encoding sequences at the N-terminal extracellular domain of the molecule.</obo_purl:IAO_0000115> <oboinowl_gen:hasExactSynonym>L-CA</oboinowl_gen:hasExactSynonym> <oboinowl_gen:hasExactSynonym>PTPRC</oboinowl_gen:hasExactSynonym> <oboinowl_gen:hasExactSynonym>leukocyte common antigen</oboinowl_gen:hasExactSynonym> <oboinowl_gen:hasExactSynonym>ly-5</oboinowl_gen:hasExactSynonym> <oboinowl_gen:hasExactSynonym>lymphocyte antigen 5</oboinowl_gen:hasExactSynonym> <oboinowl_gen:hasDbXref>IUPHARobj:1852</oboinowl_gen:hasDbXref> <oboinowl_gen:hasDbXref>PIRSF:PIRSF002004</oboinowl_gen:hasDbXref> <oboinowl_gen:hasOBONamespace>protein</oboinowl_gen:hasOBONamespace> <oboinowl_gen:id>PR:000001006</oboinowl_gen:id> <metadata_def:prefLabel>receptor-type tyrosine-protein phosphatase C</metadata_def:prefLabel> <oboinowl_gen:hasBroadSynonym>T200</oboinowl_gen:hasBroadSynonym> <oboinowl_gen:hasRelatedSynonym>CD45</oboinowl_gen:hasRelatedSynonym> <metadata_def:mappingLoom>receptortypetyrosineproteinphosphatasec</metadata_def:mappingLoom> <metadata_def:mappingSameURI rdf:resource="http://purl.obolibrary.org/obo/PR_000001006"/> </owl:Class> <rdf:Description rdf:about="http://purl.obolibrary.org/obo/PR_000001014"> <rdfs:subClassOf> <rdf:Description rdf:about="http://purl.obolibrary.org/obo/PR_000001006"> <metadata_def:mappingSameURI rdf:resource="http://purl.obolibrary.org/obo/PR_000001006"/> </rdf:Description> </rdfs:subClassOf> </rdf:Description> <rdf:Description rdf:about="http://purl.obolibrary.org/obo/PR_000001016"> <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PR_000001006"/> </rdf:Description> <rdf:Description rdf:about="http://purl.obolibrary.org/obo/PR_000001017"> <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PR_000001006"/> </rdf:Description> <rdf:Description rdf:about="http://purl.obolibrary.org/obo/PR_000018306"> <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PR_000001006"/> </rdf:Description> <rdf:Description rdf:about="http://purl.obolibrary.org/obo/PR_000025801"> <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PR_000001006"/> </rdf:Description> <rdf:Description rdf:about="http://purl.obolibrary.org/obo/PR_000025804"> <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PR_000001006"/> </rdf:Description> <rdf:Description rdf:about="http://purl.obolibrary.org/obo/PR_000050216"> <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PR_000001006"/> </rdf:Description> <rdf:Description rdf:about="http://purl.obolibrary.org/obo/PR_P04157"> <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PR_000001006"/> </rdf:Description> <rdf:Description rdf:about="http://purl.obolibrary.org/obo/PR_P06800"> <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PR_000001006"/> </rdf:Description> <rdf:Description rdf:about="http://purl.obolibrary.org/obo/PR_P08575"> <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PR_000001006"/> </rdf:Description> <rdf:Description rdf:about="http://purl.obolibrary.org/obo/PR_P35832"> <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PR_000001006"/> </rdf:Description> </rdf:RDF>