{"@context":{"obo_purl":"http://purl.obolibrary.org/obo/","rdf":"http://www.w3.org/1999/02/22-rdf-syntax-ns#","owl":"http://www.w3.org/2002/07/owl#","rdfs":"http://www.w3.org/2000/01/rdf-schema#","skos":"http://www.w3.org/2004/02/skos/core#","oboinowl_gen":"http://www.geneontology.org/formats/oboInOwl#","metadata_def":"http://data.bioontology.org/metadata/def/"},"@graph":[{"@id":"obo_purl:PR_000001006","@type":"owl:Class","rdfs:subClassOf":{"@id":"obo_purl:PR_000000001"},"rdfs:label":"receptor-type tyrosine-protein phosphatase C","rdfs:comment":"Category=gene. Requested by=CL.","skos:notation":"PR:000001006","obo_purl:IAO_0000115":"A protein that is a translation product of the human PTPRC gene or a 1:1 ortholog thereof. It is composed of an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic protein-tyrosine phosphatase domains. Contains 1 to 3 copies of the Fibronectin type III domain (Pfam:PF00041) followed by two copies of the Protein-tyrosine phosphatase (Pfam:PF00102) domain. Receptor-type tyrosine-protein phosphatase C (CD45) regulates signal transduction and lymphocyte activation by specific association with receptor molecules on T and B cells. Multiple isoforms of CD45 (180-235 kDa) can be generated asa result of alternative splicing of three variable exons 4(A), 5(B) and 6(C), encoding sequences at the N-terminal extracellular domain of the molecule.","oboinowl_gen:hasExactSynonym":["L-CA","PTPRC","leukocyte common antigen","ly-5","lymphocyte antigen 5"],"oboinowl_gen:hasDbXref":["IUPHARobj:1852","PIRSF:PIRSF002004"],"oboinowl_gen:hasOBONamespace":"protein","oboinowl_gen:id":"PR:000001006","metadata_def:prefLabel":"receptor-type tyrosine-protein phosphatase C","oboinowl_gen:hasBroadSynonym":"T200","oboinowl_gen:hasRelatedSynonym":"CD45","metadata_def:mappingLoom":"receptortypetyrosineproteinphosphatasec","metadata_def:mappingSameURI":{"@id":"obo_purl:PR_000001006"}},{"@id":"obo_purl:PR_000001014","rdfs:subClassOf":{"@id":"obo_purl:PR_000001006"}},{"@id":"obo_purl:PR_000001016","rdfs:subClassOf":{"@id":"obo_purl:PR_000001006"}},{"@id":"obo_purl:PR_000001017","rdfs:subClassOf":{"@id":"obo_purl:PR_000001006"}},{"@id":"obo_purl:PR_000050216","rdfs:subClassOf":{"@id":"obo_purl:PR_000001006"}},{"@id":"obo_purl:PR_000018306","rdfs:subClassOf":{"@id":"obo_purl:PR_000001006"}},{"@id":"obo_purl:PR_000025801","rdfs:subClassOf":{"@id":"obo_purl:PR_000001006"}},{"@id":"obo_purl:PR_000025804","rdfs:subClassOf":{"@id":"obo_purl:PR_000001006"}},{"@id":"obo_purl:PR_P06800","rdfs:subClassOf":{"@id":"obo_purl:PR_000001006"}},{"@id":"obo_purl:PR_P08575","rdfs:subClassOf":{"@id":"obo_purl:PR_000001006"}},{"@id":"obo_purl:PR_P04157","rdfs:subClassOf":{"@id":"obo_purl:PR_000001006"}},{"@id":"obo_purl:PR_P35832","rdfs:subClassOf":{"@id":"obo_purl:PR_000001006"}}]}