<?xml version="1.0" encoding="UTF-8"?> <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:obo_purl="http://purl.obolibrary.org/obo/" xmlns:owl="http://www.w3.org/2002/07/owl#" xmlns:rdfs="http://www.w3.org/2000/01/rdf-schema#" xmlns:skos="http://www.w3.org/2004/02/skos/core#" xmlns:oboinowl_gen="http://www.geneontology.org/formats/oboInOwl#" xmlns:metadata_def="http://data.bioontology.org/metadata/def/" xmlns:metadata="http://data.bioontology.org/metadata/"> <owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_1904091"> <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0003824"/> <rdfs:label>non-ribosomal peptide synthetase activity</rdfs:label> <rdfs:comment>Examples are the ferrichrome synthetase Sib1 in S. pombe and the peptidyl carrier protein (PCP) module in bacterial nonribosomal peptide synthases (NRPSs), which holds the peptidyl group and acts as a swinging arm, limiting diffusion until the peptide comes into contact with the next enzymatic module in the NRPS process.</rdfs:comment> <skos:notation>GO:1904091</skos:notation> <obo_purl:IAO_0000115>Catalysis of a multistep reaction that produce non-ribosomal peptides. The key chain-building reaction, a C-N bond-forming reaction, involves the generation of the characteristic peptide bond by nucleophilic attack of the amino group of an amino-acyl donor unit covalently bound to a downstream peptidyl carrier protein module (amino acyl-S-PCP) on the acyl group of an upstream electrophilic acyl- or peptidyl acyl-S-PCP chain, catalyzed by a condensation (C) domain. Supplementing these core chain-elongation domains are variable numbers of auxiliary domains that are responsible for modification of the growing polypeptide chain by a small set of iterated reactions including epimerization, N-methylation, and heterocyclization.</obo_purl:IAO_0000115> <oboinowl_gen:hasExactSynonym>peptidyl carrier protein activity involved in nonribosomal peptide biosynthetic process</oboinowl_gen:hasExactSynonym> <oboinowl_gen:hasExactSynonym>peptidyl carrier protein activity involved in nonribosomal peptide biosynthesis</oboinowl_gen:hasExactSynonym> <oboinowl_gen:created_by>pr</oboinowl_gen:created_by> <oboinowl_gen:creation_date>2015-03-26T10:41:52Z</oboinowl_gen:creation_date> <oboinowl_gen:hasOBONamespace>molecular_function</oboinowl_gen:hasOBONamespace> <oboinowl_gen:id>GO:1904091</oboinowl_gen:id> <metadata_def:prefLabel>non-ribosomal peptide synthetase activity</metadata_def:prefLabel> <oboinowl_gen:hasRelatedSynonym>PCP</oboinowl_gen:hasRelatedSynonym> <oboinowl_gen:hasRelatedSynonym>peptidyl carrier protein</oboinowl_gen:hasRelatedSynonym> <oboinowl_gen:hasRelatedSynonym>peptidyl carrier protein activity</oboinowl_gen:hasRelatedSynonym> <metadata_def:mappingLoom>nonribosomalpeptidesynthetaseactivity</metadata_def:mappingLoom> <metadata_def:mappingSameURI rdf:resource="http://purl.obolibrary.org/obo/GO_1904091"/> <metadata:treeView rdf:resource="http://purl.obolibrary.org/obo/GO_0019184"/> <metadata:obo/part_of rdf:resource="http://purl.obolibrary.org/obo/GO_0019184"/> <obo_purl:IAO_0000233 rdf:datatype="http://www.w3.org/2001/XMLSchema#anyURI">https://github.com/geneontology/go-ontology/issues/7340</obo_purl:IAO_0000233> </owl:Class> <rdf:Description rdf:about="http://purl.obolibrary.org/obo/GO_0004363"> <rdfs:subClassOf> <rdf:Description rdf:about="http://purl.obolibrary.org/obo/GO_1904091"> <metadata_def:mappingSameURI rdf:resource="http://purl.obolibrary.org/obo/GO_1904091"/> </rdf:Description> </rdfs:subClassOf> </rdf:Description> <rdf:Description rdf:about="http://purl.obolibrary.org/obo/GO_0097429"> <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_1904091"/> </rdf:Description> </rdf:RDF>