{"@context":{"obo_purl":"http://purl.obolibrary.org/obo/","rdf":"http://www.w3.org/1999/02/22-rdf-syntax-ns#","owl":"http://www.w3.org/2002/07/owl#","rdfs":"http://www.w3.org/2000/01/rdf-schema#","skos":"http://www.w3.org/2004/02/skos/core#","oboinowl_gen":"http://www.geneontology.org/formats/oboInOwl#","metadata_def":"http://data.bioontology.org/metadata/def/","metadata":"http://data.bioontology.org/metadata/","ns0":"http://data.bioontology.org/metadata/obo/"},"@graph":[{"@id":"obo_purl:GO_1904091","@type":"owl:Class","rdfs:subClassOf":{"@id":"obo_purl:GO_0003824"},"rdfs:label":"non-ribosomal peptide synthetase activity","rdfs:comment":"Examples are the ferrichrome synthetase Sib1 in S. pombe and the peptidyl carrier protein (PCP) module in bacterial nonribosomal peptide synthases (NRPSs), which holds the peptidyl group and acts as a swinging arm, limiting diffusion until the peptide comes into contact with the next enzymatic module in the NRPS process.","skos:notation":"GO:1904091","obo_purl:IAO_0000115":"Catalysis of a multistep reaction that produce non-ribosomal peptides. The key chain-building reaction, a C-N bond-forming reaction, involves the generation of the characteristic peptide bond by nucleophilic attack of the amino group of an amino-acyl donor unit covalently bound to a downstream peptidyl carrier protein module (amino acyl-S-PCP) on the acyl group of an upstream electrophilic acyl- or peptidyl acyl-S-PCP chain, catalyzed by a condensation (C) domain. Supplementing these core chain-elongation domains are variable numbers of auxiliary domains that are responsible for modification of the growing polypeptide chain by a small set of iterated reactions including epimerization, N-methylation, and heterocyclization.","oboinowl_gen:hasExactSynonym":["peptidyl carrier protein activity involved in nonribosomal peptide biosynthetic process","peptidyl carrier protein activity involved in nonribosomal peptide biosynthesis"],"oboinowl_gen:created_by":"pr","oboinowl_gen:creation_date":"2015-03-26T10:41:52Z","oboinowl_gen:hasOBONamespace":"molecular_function","oboinowl_gen:id":"GO:1904091","metadata:def/prefLabel":"non-ribosomal peptide synthetase activity","oboinowl_gen:hasRelatedSynonym":["PCP","peptidyl carrier protein","peptidyl carrier protein activity"],"metadata:def/mappingLoom":"nonribosomalpeptidesynthetaseactivity","metadata:def/mappingSameURI":{"@id":"obo_purl:GO_1904091"},"metadata:treeView":{"@id":"obo_purl:GO_0019184"},"metadata:obo/part_of":{"@id":"obo_purl:GO_0019184"},"obo_purl:IAO_0000233":{"@type":"http://www.w3.org/2001/XMLSchema#anyURI","@value":"https://github.com/geneontology/go-ontology/issues/7340"}},{"@id":"obo_purl:GO_0004363","rdfs:subClassOf":{"@id":"obo_purl:GO_1904091"}},{"@id":"obo_purl:GO_0097429","rdfs:subClassOf":{"@id":"obo_purl:GO_1904091"}}]}