<?xml version="1.0" encoding="UTF-8"?> <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:ns0="http://www.ebi.ac.uk/efo/" xmlns:owl="http://www.w3.org/2002/07/owl#" xmlns:rdfs="http://www.w3.org/2000/01/rdf-schema#" xmlns:obo_purl="http://purl.obolibrary.org/obo/" xmlns:oboinowl_gen="http://www.geneontology.org/formats/oboInOwl#" xmlns:metadata_def="http://data.bioontology.org/metadata/def/" xmlns:metadata="http://data.bioontology.org/metadata/"> <owl:Class rdf:about="http://www.ebi.ac.uk/efo/EFO_0005117"> <rdfs:subClassOf rdf:resource="http://www.ebi.ac.uk/efo/EFO_0001444"/> <rdfs:subClassOf rdf:resource="http://www.ebi.ac.uk/efo/EFO_0004872"/> <rdfs:subClassOf rdf:resource="http://www.ebi.ac.uk/efo/EFO_0004873"/> <rdfs:label>CCL5 measurement</rdfs:label> <obo_purl:IAO_0000115>Is the quantification of Chemokine (C-C motif) ligand 5. CCL5 is a Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant RANTES protein induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form RANTES(3-68) acts as a natural chemotaxis inhibitor and is a more potent inhibitor of HIV-1-infection. The second processed form RANTES(4-68) exhibits reduced chemotactic and HIV-suppressive activity compared with RANTES(1-68) and RANTES(3-68) and is generated by an unidentified enzyme associated with monocytes and neutrophils (PubMed:16791620, PubMed:1380064, PubMed:8525373, PubMed:9516414, PubMed:15923218). May also be an agonist of the G protein-coupled receptor GPR75, stimulating inositol trisphosphate production and calcium mobilization through its activation. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells (PubMed:23979485). </obo_purl:IAO_0000115> <obo_purl:IAO_0000117>Dani Welter</obo_purl:IAO_0000117> <oboinowl_gen:hasExactSynonym>RANTES</oboinowl_gen:hasExactSynonym> <oboinowl_gen:hasExactSynonym>Regulated on Activation, Normal T cell Expressed and Secreted</oboinowl_gen:hasExactSynonym> <obo_purl:IAO_0000136 rdf:resource="http://purl.obolibrary.org/obo/PR_000002094"/> <ns0:definition_citation>http://www.uniprot.org/uniprot/P13501</ns0:definition_citation> <ns0:gwas_trait rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">1</ns0:gwas_trait> <metadata_def:prefLabel>CCL5 measurement</metadata_def:prefLabel> <metadata_def:mappingLoom>ccl5measurement</metadata_def:mappingLoom> <metadata_def:mappingSameURI rdf:resource="http://www.ebi.ac.uk/efo/EFO_0005117"/> <metadata:prefixIRI>efo:EFO_0005117</metadata:prefixIRI> </owl:Class> <rdf:Description rdf:about="http://www.ebi.ac.uk/efo/EFO_0005117"> <metadata_def:mappingSameURI rdf:resource="http://www.ebi.ac.uk/efo/EFO_0005117"/> </rdf:Description> </rdf:RDF>