{"@context":{"ns0":"http://www.ebi.ac.uk/efo/","rdf":"http://www.w3.org/1999/02/22-rdf-syntax-ns#","owl":"http://www.w3.org/2002/07/owl#","rdfs":"http://www.w3.org/2000/01/rdf-schema#","obo_purl":"http://purl.obolibrary.org/obo/","oboinowl_gen":"http://www.geneontology.org/formats/oboInOwl#","metadata_def":"http://data.bioontology.org/metadata/def/","metadata":"http://data.bioontology.org/metadata/"},"@id":"ns0:EFO_0005117","@type":"owl:Class","rdfs:subClassOf":[{"@id":"ns0:EFO_0001444"},{"@id":"ns0:EFO_0004872"},{"@id":"ns0:EFO_0004873"}],"rdfs:label":"CCL5 measurement","obo_purl:IAO_0000115":"Is the quantification of Chemokine (C-C motif) ligand 5.\nCCL5 is a Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant RANTES protein induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form RANTES(3-68) acts as a natural chemotaxis inhibitor and is a more potent inhibitor of HIV-1-infection. The second processed form RANTES(4-68) exhibits reduced chemotactic and HIV-suppressive activity compared with RANTES(1-68) and RANTES(3-68) and is generated by an unidentified enzyme associated with monocytes and neutrophils (PubMed:16791620, PubMed:1380064, PubMed:8525373, PubMed:9516414, PubMed:15923218). May also be an agonist of the G protein-coupled receptor GPR75, stimulating inositol trisphosphate production and calcium mobilization through its activation. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells (PubMed:23979485).\n","obo_purl:IAO_0000117":"Dani Welter","oboinowl_gen:hasExactSynonym":["RANTES","Regulated on Activation, Normal T cell Expressed and Secreted"],"obo_purl:IAO_0000136":{"@id":"obo_purl:PR_000002094"},"ns0:definition_citation":"http://www.uniprot.org/uniprot/P13501","ns0:gwas_trait":{"@type":"http://www.w3.org/2001/XMLSchema#boolean","@value":"1"},"metadata:def/prefLabel":"CCL5 measurement","metadata:def/mappingLoom":"ccl5measurement","metadata:def/mappingSameURI":{"@id":"ns0:EFO_0005117"},"metadata:prefixIRI":"efo:EFO_0005117"}