<?xml version="1.0" encoding="UTF-8"?> <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:ns0="http://www.ebi.ac.uk/efo/" xmlns:owl="http://www.w3.org/2002/07/owl#" xmlns:rdfs="http://www.w3.org/2000/01/rdf-schema#" xmlns:obo_purl="http://purl.obolibrary.org/obo/" xmlns:oboinowl_gen="http://www.geneontology.org/formats/oboInOwl#" xmlns:metadata_def="http://data.bioontology.org/metadata/def/" xmlns:metadata="http://data.bioontology.org/metadata/"> <owl:Class rdf:about="http://www.ebi.ac.uk/efo/EFO_0004838"> <rdfs:subClassOf rdf:resource="http://www.ebi.ac.uk/efo/EFO_0001444"/> <rdfs:label>calcium measurement</rdfs:label> <obo_purl:IAO_0000115>Is a quantification of calcium, typically in serum. Calcium (Ca2+) plays a pivotal role in the physiology and biochemistry of organisms and the cell. It plays an important role in signal transduction pathways, where it acts as a second messenger, in neurotransmitter release from neurons, contraction of all muscle cell types, and fertilization. Many enzymes require calcium ions as a cofactor, those of the blood-clotting cascade being notable examples. Extracellular calcium is also important for maintaining the potential difference across excitable cell membranes, as well as proper bone formation.</obo_purl:IAO_0000115> <obo_purl:IAO_0000117>Helen Parkinson</obo_purl:IAO_0000117> <oboinowl_gen:hasExactSynonym>calcium levels</oboinowl_gen:hasExactSynonym> <obo_purl:IAO_0000136 rdf:resource="http://purl.obolibrary.org/obo/CHEBI_22984"/> <obo_purl:IAO_0000136 rdf:resource="http://purl.obolibrary.org/obo/CHEBI_29320"/> <oboinowl_gen:hasDbXref>NCIt:C64488</oboinowl_gen:hasDbXref> <oboinowl_gen:hasDbXref>SNOMEDCT:71878006</oboinowl_gen:hasDbXref> <ns0:definition_citation>http://en.wikipedia.org/wiki/Blood_calcium#Measurement</ns0:definition_citation> <ns0:gwas_trait rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">1</ns0:gwas_trait> <metadata_def:prefLabel>calcium measurement</metadata_def:prefLabel> <metadata_def:mappingLoom>calciummeasurement</metadata_def:mappingLoom> <metadata_def:mappingSameURI rdf:resource="http://www.ebi.ac.uk/efo/EFO_0004838"/> <metadata:prefixIRI>efo:EFO_0004838</metadata:prefixIRI> </owl:Class> <rdf:Description rdf:about="http://www.ebi.ac.uk/efo/EFO_0006521"> <rdfs:subClassOf> <rdf:Description rdf:about="http://www.ebi.ac.uk/efo/EFO_0004838"> <metadata_def:mappingSameURI rdf:resource="http://www.ebi.ac.uk/efo/EFO_0004838"/> </rdf:Description> </rdfs:subClassOf> </rdf:Description> <rdf:Description rdf:about="http://www.ebi.ac.uk/efo/EFO_0007903"> <rdfs:subClassOf rdf:resource="http://www.ebi.ac.uk/efo/EFO_0004838"/> </rdf:Description> </rdf:RDF>