{"@context":{"obo_purl":"http://purl.obolibrary.org/obo/","rdf":"http://www.w3.org/1999/02/22-rdf-syntax-ns#","owl":"http://www.w3.org/2002/07/owl#","rdfs":"http://www.w3.org/2000/01/rdf-schema#","metadata_def":"http://data.bioontology.org/metadata/def/","metadata":"http://data.bioontology.org/metadata/"},"@id":"obo_purl:NCIT_C103149","@type":"owl:Class","rdfs:subClassOf":{"@id":"obo_purl:CHEBI_24431"},"rdfs:label":"S-Adenosylhomocysteine","rdfs:comment":"An amino acid derivative and an intermediate in the synthesis of cysteine and adenosine. S-adenosylhomocysteine (SAH) is formed upon S-adenosylmethionine (SAM)-dependent methylation (homocysteine methionine cycle) of biological molecules, such as DNA, RNA, and proteins. It is then hydrolyzed by S-adenosylhomocysteine hydrolase to form adenosine and homocysteine. As SAH modulates methylation dependent reactions, SAH levels and the ratio of SAH:SAM may be used to assess methylation status of macrocolecules.","metadata:def/prefLabel":"S-Adenosylhomocysteine","metadata:def/mappingLoom":"sadenosylhomocysteine","metadata:def/mappingSameURI":{"@id":"obo_purl:NCIT_C103149"},"metadata:prefixIRI":"NCIT:C103149"}