<?xml version="1.0" encoding="UTF-8"?> <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:obo_purl="http://purl.obolibrary.org/obo/" xmlns:owl="http://www.w3.org/2002/07/owl#" xmlns:rdfs="http://www.w3.org/2000/01/rdf-schema#" xmlns:skos="http://www.w3.org/2004/02/skos/core#" xmlns:oboinowl_gen="http://www.geneontology.org/formats/oboInOwl#" xmlns:metadata_def="http://data.bioontology.org/metadata/def/"> <owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0045254"> <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0005575"/> <rdfs:label>pyruvate dehydrogenase complex</rdfs:label> <rdfs:comment>The catalytic activities of the individual components of this complex are represented by the molecular function terms 'pyruvate dehydrogenase (acetyl-transferring) activity ; GO:0004739' (E1), 'dihydrolipoyllysine-residue acetyltransferase activity ; GO:0004742' (E2), and 'dihydrolipoyl dehydrogenase activity ; GO:0004148' (E3). The overall catalytic activity of the complex is represented by the molecular function term 'pyruvate dehydrogenase (NAD+) activity ; GO:0034604'.</rdfs:comment> <skos:notation>GO:0045254</skos:notation> <obo_purl:IAO_0000115>A multi-enzyme complex that catalyzes the oxidative decarboxylation of pyruvate to form acetyl-CoA. The complex comprises multiple copies of three enzymes referred to as E1, E2 and E3: pyruvate dehydrogenase (E1, which may be a homodimer or a heterotetramer of two alpha and two beta subunits, depending on species), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3). Additional proteins may also be present.</obo_purl:IAO_0000115> <oboinowl_gen:hasExactSynonym>pyruvate dehydrogenase complex (lipoamide)</oboinowl_gen:hasExactSynonym> <oboinowl_gen:hasDbXref>Wikipedia:Pyruvate_dehydrogenase_complex</oboinowl_gen:hasDbXref> <oboinowl_gen:hasOBONamespace>cellular_component</oboinowl_gen:hasOBONamespace> <oboinowl_gen:id>GO:0045254</oboinowl_gen:id> <oboinowl_gen:inSubset rdf:resource="http://purl.obolibrary.org/obo/go#goslim_pir"/> <metadata_def:prefLabel>pyruvate dehydrogenase complex</metadata_def:prefLabel> <metadata_def:mappingLoom>pyruvatedehydrogenasecomplex</metadata_def:mappingLoom> <metadata_def:mappingSameURI rdf:resource="http://purl.obolibrary.org/obo/GO_0045254"/> <oboinowl_gen:hasAlternativeId>GO:0009364</oboinowl_gen:hasAlternativeId> <obo_purl:IAO_0000233 rdf:datatype="http://www.w3.org/2001/XMLSchema#anyURI">https://github.com/geneontology/go-ontology/issues/26881</obo_purl:IAO_0000233> <obo_purl:IAO_0000233 rdf:datatype="http://www.w3.org/2001/XMLSchema#anyURI">https://github.com/geneontology/go-ontology/issues/26122</obo_purl:IAO_0000233> </owl:Class> <rdf:Description rdf:about="http://purl.obolibrary.org/obo/MONDO_0019169"> <obo_purl:RO_0004020> <rdf:Description rdf:about="http://purl.obolibrary.org/obo/GO_0045254"> <metadata_def:mappingSameURI rdf:resource="http://purl.obolibrary.org/obo/GO_0045254"/> </rdf:Description> </obo_purl:RO_0004020> </rdf:Description> </rdf:RDF>