{"@context":{"obo_purl":"http://purl.obolibrary.org/obo/","rdf":"http://www.w3.org/1999/02/22-rdf-syntax-ns#","owl":"http://www.w3.org/2002/07/owl#","rdfs":"http://www.w3.org/2000/01/rdf-schema#","skos":"http://www.w3.org/2004/02/skos/core#","oboinowl_gen":"http://www.geneontology.org/formats/oboInOwl#","ns0":"http://purl.obolibrary.org/obo/go#","metadata_def":"http://data.bioontology.org/metadata/def/"},"@graph":[{"@id":"obo_purl:GO_0045254","@type":"owl:Class","rdfs:subClassOf":{"@id":"obo_purl:GO_0005575"},"rdfs:label":"pyruvate dehydrogenase complex","rdfs:comment":"The catalytic activities of the individual components of this complex are represented by the molecular function terms 'pyruvate dehydrogenase (acetyl-transferring) activity ; GO:0004739' (E1), 'dihydrolipoyllysine-residue acetyltransferase activity ; GO:0004742' (E2), and 'dihydrolipoyl dehydrogenase activity ; GO:0004148' (E3). The overall catalytic activity of the complex is represented by the molecular function term 'pyruvate dehydrogenase (NAD+) activity ; GO:0034604'.","skos:notation":"GO:0045254","obo_purl:IAO_0000115":"A multi-enzyme complex that catalyzes the oxidative decarboxylation of pyruvate to form acetyl-CoA. The complex comprises multiple copies of three enzymes referred to as E1, E2 and E3: pyruvate dehydrogenase (E1, which may be a homodimer or a heterotetramer of two alpha and two beta subunits, depending on species), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3). Additional proteins may also be present.","oboinowl_gen:hasExactSynonym":"pyruvate dehydrogenase complex (lipoamide)","oboinowl_gen:hasDbXref":"Wikipedia:Pyruvate_dehydrogenase_complex","oboinowl_gen:hasOBONamespace":"cellular_component","oboinowl_gen:id":"GO:0045254","oboinowl_gen:inSubset":{"@id":"ns0:goslim_pir"},"metadata_def:prefLabel":"pyruvate dehydrogenase complex","metadata_def:mappingLoom":"pyruvatedehydrogenasecomplex","metadata_def:mappingSameURI":{"@id":"obo_purl:GO_0045254"},"oboinowl_gen:hasAlternativeId":"GO:0009364","obo_purl:IAO_0000233":[{"@type":"http://www.w3.org/2001/XMLSchema#anyURI","@value":"https://github.com/geneontology/go-ontology/issues/26881"},{"@type":"http://www.w3.org/2001/XMLSchema#anyURI","@value":"https://github.com/geneontology/go-ontology/issues/26122"}]},{"@id":"obo_purl:MONDO_0019169","obo_purl:RO_0004020":{"@id":"obo_purl:GO_0045254"}}]}