<?xml version="1.0" encoding="UTF-8"?> <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:obo_purl="http://purl.obolibrary.org/obo/" xmlns:owl="http://www.w3.org/2002/07/owl#" xmlns:rdfs="http://www.w3.org/2000/01/rdf-schema#" xmlns:oboinowl_gen="http://www.geneontology.org/formats/oboInOwl#" xmlns:metadata_def="http://data.bioontology.org/metadata/def/" xmlns:metadata="http://data.bioontology.org/metadata/"> <owl:Class rdf:about="http://purl.obolibrary.org/obo/CL_0000162"> <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CL_0000066"/> <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CL_0000151"/> <rdfs:label>parietal cell</rdfs:label> <rdfs:comment>Parietal cells have dynamic, actin-supported microvilli that increase in number during active secretion, playing a crucial role in secreting hydrochloric acid and intrinsic factor. The structure and regulation of these microvilli are influenced by proteins such as ASAP3, which modulates Arf6 activity and actin assembly, thereby controlling microvilli formation and parietal cell function.</rdfs:comment> <obo_purl:IAO_0000115>An epithelial cell of the stomach that is part of the fundic gastric gland. This cell is characterized by its pyramidal shape, abundant mitochondria, and a complex network of secretory canaliculi lined with microvilli. It secretes hydrochloric acid into the stomach lumen and produces intrinsic factor, essential for vitamin B12 absorption.</obo_purl:IAO_0000115> <oboinowl_gen:hasExactSynonym>gastric parietal cell</oboinowl_gen:hasExactSynonym> <oboinowl_gen:hasExactSynonym>oxyntic cell</oboinowl_gen:hasExactSynonym> <oboinowl_gen:hasDbXref>BTO:0001780</oboinowl_gen:hasDbXref> <oboinowl_gen:hasDbXref>FMA:62901</oboinowl_gen:hasDbXref> <oboinowl_gen:hasDbXref>NCIt:C12594</oboinowl_gen:hasDbXref> <oboinowl_gen:inSubset rdf:resource="http://purl.obolibrary.org/obo/cl#human_subset"/> <oboinowl_gen:inSubset rdf:resource="http://purl.obolibrary.org/obo/cl#mouse_subset"/> <oboinowl_gen:inSubset rdf:resource="http://purl.obolibrary.org/obo/cl#cellxgene_subset"/> <metadata_def:prefLabel>parietal cell</metadata_def:prefLabel> <metadata_def:mappingLoom>parietalcell</metadata_def:mappingLoom> <metadata_def:mappingSameURI rdf:resource="http://purl.obolibrary.org/obo/CL_0000162"/> <metadata:prefixIRI>CL:0000162</metadata:prefixIRI> <obo_purl:RO_0001025 rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000945"/> </owl:Class> <rdf:Description rdf:about="http://purl.obolibrary.org/obo/CL_0000162"> <metadata_def:mappingSameURI rdf:resource="http://purl.obolibrary.org/obo/CL_0000162"/> </rdf:Description> </rdf:RDF>