<?xml version="1.0" encoding="UTF-8"?> <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:obo_purl="http://purl.obolibrary.org/obo/" xmlns:owl="http://www.w3.org/2002/07/owl#" xmlns:rdfs="http://www.w3.org/2000/01/rdf-schema#" xmlns:ns0="http://www.ebi.ac.uk/efo/" xmlns:oboinowl_gen="http://www.geneontology.org/formats/oboInOwl#" xmlns:dct="http://purl.org/dc/terms/" xmlns:metadata_def="http://data.bioontology.org/metadata/def/" xmlns:metadata="http://data.bioontology.org/metadata/"> <owl:Class rdf:about="http://purl.obolibrary.org/obo/CL_0000062"> <rdfs:subClassOf rdf:resource="http://www.ebi.ac.uk/efo/EFO_0000324"/> <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CL_0000000"/> <rdfs:label>osteoblast</rdfs:label> <rdfs:comment>non-encoded relationships from VSAO - capable_of_producing VSAO:0000020</rdfs:comment> <rdfs:seeAlso>https://cellxgene.cziscience.com/cellguide/CL_0000062</rdfs:seeAlso> <obo_purl:IAO_0000115>Skeletogenic cell that secretes osteoid, is capable of producing mineralized (hydroxyapatite) matrix, is located adjacent to or within osteoid tissue, and arises from the transformation of a preosteoblast cell.</obo_purl:IAO_0000115> <oboinowl_gen:hasDbXref>BTO:0001593</oboinowl_gen:hasDbXref> <oboinowl_gen:hasDbXref>CALOHA:TS-0720</oboinowl_gen:hasDbXref> <oboinowl_gen:hasDbXref>FMA:66780</oboinowl_gen:hasDbXref> <oboinowl_gen:hasDbXref>NCIt:C12568</oboinowl_gen:hasDbXref> <oboinowl_gen:hasDbXref>SNOMEDCT:48156001</oboinowl_gen:hasDbXref> <oboinowl_gen:hasDbXref>ZFA:0009031</oboinowl_gen:hasDbXref> <oboinowl_gen:inSubset rdf:resource="http://purl.obolibrary.org/obo/cl#human_subset"/> <oboinowl_gen:inSubset rdf:resource="http://purl.obolibrary.org/obo/cl#mouse_subset"/> <oboinowl_gen:inSubset rdf:resource="http://purl.obolibrary.org/obo/cl#cellxgene_subset"/> <dct:description>Osteoblasts are a type of bone cell primarily responsible for bone formation. Osteoblasts are derived from mesenchymal stem cells, which differentiate into osteoblasts under the influence of various growth factors, including bone morphogenetic proteins (BMPs). These multipotent cells play a critical role in the bone formation process known as ossification. The primary function of osteoblasts is to synthesize and deposit bone matrix, a mixture of organic substances and inorganic materials. This included producing a mix of collagen and non-collagenous proteins, which they secrete to create the organic portion of the extracellular bone matrix. The osteoblasts also initiate the mineralization process by depositing calcium and phosphate ions onto this organic matrix, generating a material that is incredibly strong and resilient, which we recognize as bone. Furthermore, osteoblasts are intricately involved in bone remodeling. They communicate with other specialized bone cells, like osteoclasts (involved in bone resorption) and osteocytes (derived from osteoblasts and important for bone maintenance), helping to maintain skeletal health and homeostasis. Dysregulation of osteoblast function can lead to various bone diseases, illustrating the importance of these cells in skeletal health and development. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)</dct:description> <metadata_def:prefLabel>osteoblast</metadata_def:prefLabel> <metadata_def:mappingLoom>osteoblast</metadata_def:mappingLoom> <metadata_def:mappingSameURI rdf:resource="http://purl.obolibrary.org/obo/CL_0000062"/> <metadata:prefixIRI>CL:0000062</metadata:prefixIRI> <obo_purl:RO_0001025 rdf:resource="http://purl.obolibrary.org/obo/UBERON_0001474"/> </owl:Class> <rdf:Description rdf:about="http://purl.obolibrary.org/obo/CL_2000058"> <rdfs:subClassOf> <rdf:Description rdf:about="http://purl.obolibrary.org/obo/CL_0000062"> <metadata_def:mappingSameURI rdf:resource="http://purl.obolibrary.org/obo/CL_0000062"/> </rdf:Description> </rdfs:subClassOf> </rdf:Description> <rdf:Description rdf:about="http://www.ebi.ac.uk/efo/EFO_0010232"> <obo_purl:IAO_0000136 rdf:resource="http://purl.obolibrary.org/obo/CL_0000062"/> </rdf:Description> </rdf:RDF>