{"@context":{"obo_purl":"http://purl.obolibrary.org/obo/","rdf":"http://www.w3.org/1999/02/22-rdf-syntax-ns#","owl":"http://www.w3.org/2002/07/owl#","rdfs":"http://www.w3.org/2000/01/rdf-schema#","skos":"http://www.w3.org/2004/02/skos/core#","oboinowl_gen":"http://www.geneontology.org/formats/oboInOwl#","ns0":"http://purl.obolibrary.org/obo/chebi#","ns1":"http://purl.obolibrary.org/obo#","metadata_def":"http://data.bioontology.org/metadata/def/","ns2":"http://purl.obolibrary.org/obo/chebi/"},"@id":"obo_purl:CHEBI_52717","@type":"owl:Class","rdfs:subClassOf":[{"@id":"obo_purl:CHEBI_24532"},{"@id":"obo_purl:CHEBI_37622"}],"rdfs:label":"bortezomib","skos:notation":"CHEBI:52717","obo_purl:IAO_0000115":"L-Phenylalaninamide substituted at the amide nitrogen by a 1-(dihydroxyboranyl)-3-methylbutyl group and at N(alpha) by a pyrazin-2-ylcarbonyl group. It is a dipeptidyl boronic acid that reversibly inhibits the 26S proteasome.","oboinowl_gen:hasExactSynonym":["[(1R)-3-methyl-1-({(2S)-3-phenyl-2-[(pyrazin-2-ylcarbonyl)amino]propanoyl}amino)butyl]boronic acid","bortezomib","N-[(1R)-1-(dihydroxyboranyl)-3-methylbutyl]-N(alpha)-(pyrazin-2-ylcarbonyl)-L-phenylalaninamide"],"oboinowl_gen:hasDbXref":["CAS:179324-69-7","DrugBank:DB00188","Drug_Central:391","KEGG:D03150","LINCS:LSM-6281","NCIt:C1851","PDBeChem:BO2","PMID:18484921","PMID:18980173","PMID:21504411","PMID:21865767","Reaxys:8723817","SNOMEDCT:398907002","SNOMEDCT:407097007","Wikipedia:Bortezomib","MESH:C400082"],"oboinowl_gen:hasOBONamespace":"chebi_ontology","oboinowl_gen:id":"CHEBI:52717","oboinowl_gen:inSubset":{"@id":"ns0:3_STAR"},"ns1:has_role":{"@id":"obo_purl:CHEBI_35610"},"metadata_def:prefLabel":"bortezomib","oboinowl_gen:hasRelatedSynonym":["PS 341","PS-341","Velcade","bortezomib","N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE"],"metadata_def:mappingLoom":"bortezomib","metadata_def:mappingSameURI":{"@id":"obo_purl:CHEBI_52717"},"oboinowl_gen:hasAlternativeId":"CHEBI:41143","ns2:charge":"0","ns2:formula":"C19H25BN4O4","ns2:inchi":"InChI=1S/C19H25BN4O4/c1-13(2)10-17(20(27)28)24-18(25)15(11-14-6-4-3-5-7-14)23-19(26)16-12-21-8-9-22-16/h3-9,12-13,15,17,27-28H,10-11H2,1-2H3,(H,23,26)(H,24,25)/t15-,17-/m0/s1","ns2:inchikey":"GXJABQQUPOEUTA-RDJZCZTQSA-N","ns2:mass":"384.23700","ns2:monoisotopicmass":"384.19689","ns2:smiles":"CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)c1cnccn1)B(O)O"}