@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix obo_purl: <http://purl.obolibrary.org/obo/> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix skos: <http://www.w3.org/2004/02/skos/core#> .
@prefix oboinowl_gen: <http://www.geneontology.org/formats/oboInOwl#> .
@prefix ns0: <http://purl.obolibrary.org/obo/chebi#> .
@prefix metadata_def: <http://data.bioontology.org/metadata/def/> .
@prefix ns1: <http://purl.obolibrary.org/obo#> .
obo_purl:CHEBI_50276
metadata_def:mappingLoom "ec59912dnatopoisomeraseinhibitor" ;
metadata_def:mappingSameURI obo_purl:CHEBI_50276 ;
metadata_def:prefLabel "EC 5.99.1.2 (DNA topoisomerase) inhibitor" ;
obo_purl:IAO_0000115 "A topoisomerase inhibitor that inhibits the bacterial enzymes of the DNA topoisomerases, Type I class (EC 5.99.1.2) that catalyze ATP-independent breakage of one of the two strands of DNA, passage of the unbroken strand through the break, and rejoining of the broken strand. These bacterial enzymes reduce the topological stress in the DNA structure by relaxing negatively, but not positively, supercoiled DNA." ;
oboinowl_gen:hasDbXref "MESH:D059004" ;
oboinowl_gen:hasOBONamespace "chebi_ontology" ;
oboinowl_gen:hasRelatedSynonym "DNA topoisomerase inhibitor", "DNA topoisomerase inhibitors", "EC 5.99.1.2 (DNA topoisomerase) inhibitors", "EC 5.99.1.2 (topoisomerase I) inhibitor", "EC 5.99.1.2 (topoisomerase I) inhibitors", "EC 5.99.1.2 inhibitor", "EC 5.99.1.2 inhibitors", "topoisomerase I (EC 5.99.1.2) inhibitor", "topoisomerase I (EC 5.99.1.2) inhibitors", "topoisomerase I inhibitor", "topoisomerase I inhibitors", "type I DNA topoisomerase inhibitor", "type I DNA topoisomerase inhibitors" ;
oboinowl_gen:id "CHEBI:50276" ;
oboinowl_gen:inSubset <http://purl.obolibrary.org/obo/chebi#3_STAR> ;
a owl:Class ;
rdfs:label "EC 5.99.1.2 (DNA topoisomerase) inhibitor" ;
rdfs:subClassOf obo_purl:CHEBI_23924 ;
skos:notation "CHEBI:50276" .
obo_purl:CHEBI_63632
ns1:has_role obo_purl:CHEBI_50276 .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix obo_purl: <http://purl.obolibrary.org/obo/> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix skos: <http://www.w3.org/2004/02/skos/core#> .
@prefix oboinowl_gen: <http://www.geneontology.org/formats/oboInOwl#> .
@prefix ns0: <http://purl.obolibrary.org/obo/chebi#> .
@prefix metadata_def: <http://data.bioontology.org/metadata/def/> .
@prefix ns1: <http://purl.obolibrary.org/obo#> .
obo_purl:CHEBI_50276
metadata_def:mappingLoom "ec59912dnatopoisomeraseinhibitor" ;
metadata_def:mappingSameURI obo_purl:CHEBI_50276 ;
metadata_def:prefLabel "EC 5.99.1.2 (DNA topoisomerase) inhibitor" ;
obo_purl:IAO_0000115 "A topoisomerase inhibitor that inhibits the bacterial enzymes of the DNA topoisomerases, Type I class (EC 5.99.1.2) that catalyze ATP-independent breakage of one of the two strands of DNA, passage of the unbroken strand through the break, and rejoining of the broken strand. These bacterial enzymes reduce the topological stress in the DNA structure by relaxing negatively, but not positively, supercoiled DNA." ;
oboinowl_gen:hasDbXref "MESH:D059004" ;
oboinowl_gen:hasOBONamespace "chebi_ontology" ;
oboinowl_gen:hasRelatedSynonym "DNA topoisomerase inhibitor", "DNA topoisomerase inhibitors", "EC 5.99.1.2 (DNA topoisomerase) inhibitors", "EC 5.99.1.2 (topoisomerase I) inhibitor", "EC 5.99.1.2 (topoisomerase I) inhibitors", "EC 5.99.1.2 inhibitor", "EC 5.99.1.2 inhibitors", "topoisomerase I (EC 5.99.1.2) inhibitor", "topoisomerase I (EC 5.99.1.2) inhibitors", "topoisomerase I inhibitor", "topoisomerase I inhibitors", "type I DNA topoisomerase inhibitor", "type I DNA topoisomerase inhibitors" ;
oboinowl_gen:id "CHEBI:50276" ;
oboinowl_gen:inSubset <http://purl.obolibrary.org/obo/chebi#3_STAR> ;
a owl:Class ;
rdfs:label "EC 5.99.1.2 (DNA topoisomerase) inhibitor" ;
rdfs:subClassOf obo_purl:CHEBI_23924 ;
skos:notation "CHEBI:50276" .
obo_purl:CHEBI_63632
ns1:has_role obo_purl:CHEBI_50276 .