<?xml version="1.0" encoding="UTF-8"?> <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:obo_purl="http://purl.obolibrary.org/obo/" xmlns:owl="http://www.w3.org/2002/07/owl#" xmlns:rdfs="http://www.w3.org/2000/01/rdf-schema#" xmlns:skos="http://www.w3.org/2004/02/skos/core#" xmlns:oboinowl_gen="http://www.geneontology.org/formats/oboInOwl#" xmlns:metadata_def="http://data.bioontology.org/metadata/def/"> <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_27899"> <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_24431"/> <rdfs:label>cisplatin</rdfs:label> <skos:notation>CHEBI:27899</skos:notation> <obo_purl:IAO_0000115>A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).</obo_purl:IAO_0000115> <oboinowl_gen:hasExactSynonym>(SP-4-2)-diamminedichloridoplatinum</oboinowl_gen:hasExactSynonym> <oboinowl_gen:hasExactSynonym>(SP-4-2)-diamminedichloroplatinum</oboinowl_gen:hasExactSynonym> <oboinowl_gen:hasExactSynonym>Cisplatin</oboinowl_gen:hasExactSynonym> <oboinowl_gen:hasExactSynonym>cis-diamminedichloridoplatinum(II)</oboinowl_gen:hasExactSynonym> <oboinowl_gen:hasExactSynonym>cis-diamminedichloroplatinum(II)</oboinowl_gen:hasExactSynonym> <oboinowl_gen:hasDbXref>CAS:15663-27-1</oboinowl_gen:hasDbXref> <oboinowl_gen:hasDbXref>DrugBank:DB00515</oboinowl_gen:hasDbXref> <oboinowl_gen:hasDbXref>Gmelin:2519</oboinowl_gen:hasDbXref> <oboinowl_gen:hasDbXref>HMDB:HMDB0014656</oboinowl_gen:hasDbXref> <oboinowl_gen:hasDbXref>KEGG:C06911</oboinowl_gen:hasDbXref> <oboinowl_gen:hasDbXref>KEGG:D00275</oboinowl_gen:hasDbXref> <oboinowl_gen:hasDbXref>MetaCyc:CPD0-1392</oboinowl_gen:hasDbXref> <oboinowl_gen:hasDbXref>MolBase:25</oboinowl_gen:hasDbXref> <oboinowl_gen:hasDbXref>PMID:10883661</oboinowl_gen:hasDbXref> <oboinowl_gen:hasDbXref>PMID:12537968</oboinowl_gen:hasDbXref> <oboinowl_gen:hasDbXref>PMID:12831510</oboinowl_gen:hasDbXref> <oboinowl_gen:hasDbXref>PMID:12935404</oboinowl_gen:hasDbXref> <oboinowl_gen:hasDbXref>PMID:16327988</oboinowl_gen:hasDbXref> <oboinowl_gen:hasDbXref>PMID:18472761</oboinowl_gen:hasDbXref> <oboinowl_gen:hasDbXref>PMID:1855275</oboinowl_gen:hasDbXref> <oboinowl_gen:hasDbXref>PMID:23554447</oboinowl_gen:hasDbXref> <oboinowl_gen:hasDbXref>PMID:23604226</oboinowl_gen:hasDbXref> <oboinowl_gen:hasDbXref>PMID:23651576</oboinowl_gen:hasDbXref> <oboinowl_gen:hasDbXref>PMID:28494534</oboinowl_gen:hasDbXref> <oboinowl_gen:hasDbXref>Patent:DE2318020</oboinowl_gen:hasDbXref> <oboinowl_gen:hasDbXref>Patent:DE2329485</oboinowl_gen:hasDbXref> <oboinowl_gen:hasDbXref>Reaxys:11324567</oboinowl_gen:hasDbXref> <oboinowl_gen:hasDbXref>Wikipedia:Cisplatin</oboinowl_gen:hasDbXref> <oboinowl_gen:hasDbXref>ChEMBL:428069</oboinowl_gen:hasDbXref> <oboinowl_gen:hasDbXref>ChemIDplus:15663-27-1</oboinowl_gen:hasDbXref> <oboinowl_gen:hasDbXref>KEGG COMPOUND:15663-27-1</oboinowl_gen:hasDbXref> <oboinowl_gen:hasDbXref>KEGG COMPOUND:C06911</oboinowl_gen:hasDbXref> <oboinowl_gen:hasDbXref>KEGG DRUG:D00275</oboinowl_gen:hasDbXref> <oboinowl_gen:hasDbXref>NCIt:C376</oboinowl_gen:hasDbXref> <oboinowl_gen:hasDbXref>SNOMEDCT:387318005</oboinowl_gen:hasDbXref> <oboinowl_gen:hasDbXref>SNOMEDCT:57066004</oboinowl_gen:hasDbXref> <oboinowl_gen:hasDbXref>MESH:D002945</oboinowl_gen:hasDbXref> <oboinowl_gen:hasOBONamespace>chebi_ontology</oboinowl_gen:hasOBONamespace> <oboinowl_gen:id>CHEBI:27899</oboinowl_gen:id> <oboinowl_gen:inSubset rdf:resource="http://purl.obolibrary.org/obo/chebi#3_STAR"/> <metadata_def:prefLabel>cisplatin</metadata_def:prefLabel> <oboinowl_gen:hasRelatedSynonym>cisplatin</oboinowl_gen:hasRelatedSynonym> <oboinowl_gen:hasRelatedSynonym>Briplatin</oboinowl_gen:hasRelatedSynonym> <oboinowl_gen:hasRelatedSynonym>CDDP</oboinowl_gen:hasRelatedSynonym> <oboinowl_gen:hasRelatedSynonym>Cismaplat</oboinowl_gen:hasRelatedSynonym> <oboinowl_gen:hasRelatedSynonym>Lederplatin</oboinowl_gen:hasRelatedSynonym> <oboinowl_gen:hasRelatedSynonym>Neoplatin</oboinowl_gen:hasRelatedSynonym> <oboinowl_gen:hasRelatedSynonym>Peyrone's chloride</oboinowl_gen:hasRelatedSynonym> <oboinowl_gen:hasRelatedSynonym>Peyrone's salt</oboinowl_gen:hasRelatedSynonym> <oboinowl_gen:hasRelatedSynonym>Platamine</oboinowl_gen:hasRelatedSynonym> <oboinowl_gen:hasRelatedSynonym>Platinex</oboinowl_gen:hasRelatedSynonym> <oboinowl_gen:hasRelatedSynonym>Platinol</oboinowl_gen:hasRelatedSynonym> <oboinowl_gen:hasRelatedSynonym>Randa</oboinowl_gen:hasRelatedSynonym> <oboinowl_gen:hasRelatedSynonym>[PtCl2(NH3)2]</oboinowl_gen:hasRelatedSynonym> <oboinowl_gen:hasRelatedSynonym>cis-DDP</oboinowl_gen:hasRelatedSynonym> <oboinowl_gen:hasRelatedSynonym>cis-Diamminedichloroplatinum(II)</oboinowl_gen:hasRelatedSynonym> <oboinowl_gen:hasRelatedSynonym>cis-[PtCl2(NH3)2]</oboinowl_gen:hasRelatedSynonym> <oboinowl_gen:hasRelatedSynonym>cis-diamminedichloroplatinum</oboinowl_gen:hasRelatedSynonym> <oboinowl_gen:hasRelatedSynonym>cis-diammineplatinum(II) dichloride</oboinowl_gen:hasRelatedSynonym> <oboinowl_gen:hasRelatedSynonym>cis-dichlorodiammineplatinum(II)</oboinowl_gen:hasRelatedSynonym> <oboinowl_gen:hasRelatedSynonym>cis-platin</oboinowl_gen:hasRelatedSynonym> <oboinowl_gen:hasRelatedSynonym>cisplatine</oboinowl_gen:hasRelatedSynonym> <oboinowl_gen:hasRelatedSynonym>cisplatino</oboinowl_gen:hasRelatedSynonym> <oboinowl_gen:hasRelatedSynonym>cisplatinum</oboinowl_gen:hasRelatedSynonym> <metadata_def:mappingLoom>cisplatin</metadata_def:mappingLoom> <metadata_def:mappingSameURI rdf:resource="http://purl.obolibrary.org/obo/CHEBI_27899"/> <oboinowl_gen:hasAlternativeId>CHEBI:23314</oboinowl_gen:hasAlternativeId> <oboinowl_gen:hasAlternativeId>CHEBI:3722</oboinowl_gen:hasAlternativeId> <obo_purl:chebi/charge>0</obo_purl:chebi/charge> <obo_purl:chebi/formula>Cl2H6N2Pt</obo_purl:chebi/formula> <obo_purl:chebi/formula>H6Cl2N2Pt</obo_purl:chebi/formula> <obo_purl:chebi/inchi>InChI=1S/2ClH.2H3N.Pt/h2*1H;2*1H3;/q;;;;+2/p-2</obo_purl:chebi/inchi> <obo_purl:chebi/inchikey>LXZZYRPGZAFOLE-UHFFFAOYSA-L</obo_purl:chebi/inchikey> <obo_purl:chebi/mass>300.04452</obo_purl:chebi/mass> <obo_purl:chebi/monoisotopicmass>298.95560</obo_purl:chebi/monoisotopicmass> <obo_purl:chebi/smiles>[H][N]([H])([H])[Pt](Cl)(Cl)[N]([H])([H])[H]</obo_purl:chebi/smiles> </owl:Class> <rdf:Description rdf:about="http://purl.obolibrary.org/obo/GO_0072718"> <obo_purl:IAO_0000136> <rdf:Description rdf:about="http://purl.obolibrary.org/obo/CHEBI_27899"> <metadata_def:mappingSameURI rdf:resource="http://purl.obolibrary.org/obo/CHEBI_27899"/> </rdf:Description> </obo_purl:IAO_0000136> </rdf:Description> </rdf:RDF>