<?xml version="1.0" encoding="UTF-8"?> <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:obo_purl="http://purl.obolibrary.org/obo/" xmlns:owl="http://www.w3.org/2002/07/owl#" xmlns:rdfs="http://www.w3.org/2000/01/rdf-schema#" xmlns:skos="http://www.w3.org/2004/02/skos/core#" xmlns:oboinowl_gen="http://www.geneontology.org/formats/oboInOwl#" xmlns:metadata_def="http://data.bioontology.org/metadata/def/" xmlns:ns0="http://purl.obolibrary.org/obo/chebi#" xmlns:ns1="http://purl.obolibrary.org/obo/chebi#"> <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_63618"> <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33308"/> <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_35681"/> <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_35868"/> <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_36785"/> <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_61355"/> <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_87633"/> <rdfs:label>pravastatin</rdfs:label> <skos:notation>CHEBI:63618</skos:notation> <obo_purl:IAO_0000115>A carboxylic ester resulting from the formal condensation of (S)-2-methylbutyric acid with the hydroxy group adjacent to the ring junction of (3R,5R)-7-[(1S,2S,6S,8S,8aR)-6,8-dihydroxy-2-methyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoic acid. Derived from microbial transformation of mevastatin, pravastatin is a reversible inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA). The sodium salt is used for lowering cholesterol and preventing cardiovascular disease. It is one of the lower potency statins, but has the advantage of fewer side effects compared with lovastatin and simvastatin.</obo_purl:IAO_0000115> <oboinowl_gen:hasExactSynonym>(3R,5R)-3,5-dihydroxy-7-[(1S,2S,6S,8S,8aR)-6-hydroxy-2-methyl-8-{[(2S)-2-methylbutanoyl]oxy}-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]heptanoic acid</oboinowl_gen:hasExactSynonym> <oboinowl_gen:hasDbXref>PMID:21749370</oboinowl_gen:hasDbXref> <oboinowl_gen:hasDbXref>CAS:81093-37-0</oboinowl_gen:hasDbXref> <oboinowl_gen:hasDbXref>DrugBank:DB00175</oboinowl_gen:hasDbXref> <oboinowl_gen:hasDbXref>Drug_Central:2239</oboinowl_gen:hasDbXref> <oboinowl_gen:hasDbXref>HMDB:HMDB0005022</oboinowl_gen:hasDbXref> <oboinowl_gen:hasDbXref>KEGG:C01844</oboinowl_gen:hasDbXref> <oboinowl_gen:hasDbXref>KEGG:D08410</oboinowl_gen:hasDbXref> <oboinowl_gen:hasDbXref>KNApSAcK:C00000565</oboinowl_gen:hasDbXref> <oboinowl_gen:hasDbXref>LINCS:LSM-3347</oboinowl_gen:hasDbXref> <oboinowl_gen:hasDbXref>PMID:21851379</oboinowl_gen:hasDbXref> <oboinowl_gen:hasDbXref>PMID:25264019</oboinowl_gen:hasDbXref> <oboinowl_gen:hasDbXref>Reaxys:4825538</oboinowl_gen:hasDbXref> <oboinowl_gen:hasDbXref>Wikipedia:Pravastatin</oboinowl_gen:hasDbXref> <oboinowl_gen:hasOBONamespace>chebi_ontology</oboinowl_gen:hasOBONamespace> <oboinowl_gen:id>CHEBI:63618</oboinowl_gen:id> <oboinowl_gen:inSubset rdf:resource="http://purl.obolibrary.org/obo/chebi#3_STAR"/> <metadata_def:prefLabel>pravastatin</metadata_def:prefLabel> <oboinowl_gen:hasRelatedSynonym>(+)-(3R,5R)-3,5-dihydroxy-7-[(1S,2S,6S,8S,8aR)-6-hydroxy-2-methyl-8-{[(S)-2-methylbutyryl]oxy}-1,2,6,7,8,8a-hexahydro-1-naphthyl]heptanoic acid</oboinowl_gen:hasRelatedSynonym> <oboinowl_gen:hasRelatedSynonym>pravastatin</oboinowl_gen:hasRelatedSynonym> <oboinowl_gen:hasRelatedSynonym>pravastatin acid</oboinowl_gen:hasRelatedSynonym> <oboinowl_gen:hasRelatedSynonym>pravastatina</oboinowl_gen:hasRelatedSynonym> <oboinowl_gen:hasRelatedSynonym>pravastatine</oboinowl_gen:hasRelatedSynonym> <oboinowl_gen:hasRelatedSynonym>pravastatinum</oboinowl_gen:hasRelatedSynonym> <metadata_def:mappingLoom>pravastatin</metadata_def:mappingLoom> <metadata_def:mappingSameURI rdf:resource="http://purl.obolibrary.org/obo/CHEBI_63618"/> <oboinowl_gen:hasAlternativeId>CHEBI:8360</oboinowl_gen:hasAlternativeId> <obo_purl:RO_0000087 rdf:resource="http://purl.obolibrary.org/obo/CHEBI_35703"/> <obo_purl:RO_0000087 rdf:resource="http://purl.obolibrary.org/obo/CHEBI_78298"/> <obo_purl:RO_0000087 rdf:resource="http://purl.obolibrary.org/obo/CHEBI_25212"/> <obo_purl:chebi/charge>0</obo_purl:chebi/charge> <obo_purl:chebi/formula>C23H36O7</obo_purl:chebi/formula> <obo_purl:chebi/inchi>InChI=1S/C23H36O7/c1-4-13(2)23(29)30-20-11-17(25)9-15-6-5-14(3)19(22(15)20)8-7-16(24)10-18(26)12-21(27)28/h5-6,9,13-14,16-20,22,24-26H,4,7-8,10-12H2,1-3H3,(H,27,28)/t13-,14-,16+,17+,18+,19-,20-,22-/m0/s1</obo_purl:chebi/inchi> <obo_purl:chebi/inchikey>TUZYXOIXSAXUGO-PZAWKZKUSA-N</obo_purl:chebi/inchikey> <obo_purl:chebi/mass>424.52770</obo_purl:chebi/mass> <obo_purl:chebi/monoisotopicmass>424.24610</obo_purl:chebi/monoisotopicmass> <obo_purl:chebi/smiles>[H][C@]12[C@H](C[C@H](O)C=C1C=C[C@H](C)[C@@H]2CC[C@@H](O)C[C@@H](O)CC(O)=O)OC(=O)[C@@H](C)CC</obo_purl:chebi/smiles> <ns0:is_conjugate_acid_of rdf:resource="http://purl.obolibrary.org/obo/CHEBI_63660"/> <ns1:has_functional_parent rdf:resource="http://purl.obolibrary.org/obo/CHEBI_38655"/> <ns1:has_functional_parent rdf:resource="http://purl.obolibrary.org/obo/CHEBI_63655"/> </owl:Class> <rdf:Description rdf:about="http://purl.obolibrary.org/obo/CHEBI_63660"> <ns0:is_conjugate_base_of> <rdf:Description rdf:about="http://purl.obolibrary.org/obo/CHEBI_63618"> <metadata_def:mappingSameURI rdf:resource="http://purl.obolibrary.org/obo/CHEBI_63618"/> </rdf:Description> </ns0:is_conjugate_base_of> </rdf:Description> <rdf:Description rdf:about="http://purl.obolibrary.org/obo/ECTO_9000753"> <obo_purl:RO_0002309 rdf:resource="http://purl.obolibrary.org/obo/CHEBI_63618"/> </rdf:Description> </rdf:RDF>