<?xml version="1.0" encoding="UTF-8"?> <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:obo_purl="http://purl.obolibrary.org/obo/" xmlns:owl="http://www.w3.org/2002/07/owl#" xmlns:rdfs="http://www.w3.org/2000/01/rdf-schema#" xmlns:skos="http://www.w3.org/2004/02/skos/core#" xmlns:oboinowl_gen="http://www.geneontology.org/formats/oboInOwl#" xmlns:metadata_def="http://data.bioontology.org/metadata/def/"> <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_5778"> <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_36683"/> <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_35358"/> <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_50265"/> <rdfs:label>hydrochlorothiazide</rdfs:label> <skos:notation>CHEBI:5778</skos:notation> <obo_purl:IAO_0000115>A benzothiadiazine that is 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide substituted by a chloro group at position 6 and a sulfonamide at 7. It is diuretic used for the treatment of hypertension and congestive heart failure.</obo_purl:IAO_0000115> <oboinowl_gen:hasExactSynonym>6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide</oboinowl_gen:hasExactSynonym> <oboinowl_gen:hasDbXref>CAS:58-93-5</oboinowl_gen:hasDbXref> <oboinowl_gen:hasDbXref>DrugBank:DB00999</oboinowl_gen:hasDbXref> <oboinowl_gen:hasDbXref>Drug_Central:1385</oboinowl_gen:hasDbXref> <oboinowl_gen:hasDbXref>HMDB:HMDB0001928</oboinowl_gen:hasDbXref> <oboinowl_gen:hasDbXref>KEGG:C07041</oboinowl_gen:hasDbXref> <oboinowl_gen:hasDbXref>KEGG:D00340</oboinowl_gen:hasDbXref> <oboinowl_gen:hasDbXref>LINCS:LSM-5308</oboinowl_gen:hasDbXref> <oboinowl_gen:hasDbXref>PDBeChem:HCZ</oboinowl_gen:hasDbXref> <oboinowl_gen:hasDbXref>PMID:24055851</oboinowl_gen:hasDbXref> <oboinowl_gen:hasDbXref>PMID:24657333</oboinowl_gen:hasDbXref> <oboinowl_gen:hasDbXref>PMID:24849193</oboinowl_gen:hasDbXref> <oboinowl_gen:hasDbXref>Reaxys:625101</oboinowl_gen:hasDbXref> <oboinowl_gen:hasDbXref>Wikipedia:Hydrochlorothiazide</oboinowl_gen:hasDbXref> <oboinowl_gen:hasOBONamespace>chebi_ontology</oboinowl_gen:hasOBONamespace> <oboinowl_gen:id>CHEBI:5778</oboinowl_gen:id> <oboinowl_gen:inSubset rdf:resource="http://purl.obolibrary.org/obo/chebi#3_STAR"/> <metadata_def:prefLabel>hydrochlorothiazide</metadata_def:prefLabel> <oboinowl_gen:hasRelatedSynonym>Esidrix (TN)</oboinowl_gen:hasRelatedSynonym> <oboinowl_gen:hasRelatedSynonym>hidroclorotiazida</oboinowl_gen:hasRelatedSynonym> <oboinowl_gen:hasRelatedSynonym>hydrochlorothiazide</oboinowl_gen:hasRelatedSynonym> <oboinowl_gen:hasRelatedSynonym>hydrochlorothiazidum</oboinowl_gen:hasRelatedSynonym> <metadata_def:mappingLoom>hydrochlorothiazide</metadata_def:mappingLoom> <metadata_def:mappingSameURI rdf:resource="http://purl.obolibrary.org/obo/CHEBI_5778"/> <obo_purl:RO_0000087 rdf:resource="http://purl.obolibrary.org/obo/CHEBI_35498"/> <obo_purl:RO_0000087 rdf:resource="http://purl.obolibrary.org/obo/CHEBI_35703"/> <obo_purl:RO_0000087 rdf:resource="http://purl.obolibrary.org/obo/CHEBI_35674"/> <obo_purl:RO_0000087 rdf:resource="http://purl.obolibrary.org/obo/CHEBI_78298"/> <obo_purl:chebi/charge>0</obo_purl:chebi/charge> <obo_purl:chebi/formula>C7H8ClN3O4S2</obo_purl:chebi/formula> <obo_purl:chebi/inchi>InChI=1S/C7H8ClN3O4S2/c8-4-1-5-7(2-6(4)16(9,12)13)17(14,15)11-3-10-5/h1-2,10-11H,3H2,(H2,9,12,13)</obo_purl:chebi/inchi> <obo_purl:chebi/inchikey>JZUFKLXOESDKRF-UHFFFAOYSA-N</obo_purl:chebi/inchikey> <obo_purl:chebi/mass>297.73900</obo_purl:chebi/mass> <obo_purl:chebi/monoisotopicmass>296.96448</obo_purl:chebi/monoisotopicmass> <obo_purl:chebi/smiles>NS(=O)(=O)c1cc2c(NCNS2(=O)=O)cc1Cl</obo_purl:chebi/smiles> </owl:Class> <rdf:Description rdf:about="http://purl.obolibrary.org/obo/ECTO_9000741"> <obo_purl:RO_0002309> <rdf:Description rdf:about="http://purl.obolibrary.org/obo/CHEBI_5778"> <metadata_def:mappingSameURI rdf:resource="http://purl.obolibrary.org/obo/CHEBI_5778"/> </rdf:Description> </obo_purl:RO_0002309> </rdf:Description> </rdf:RDF>