{"@context":{"obo_purl":"http://purl.obolibrary.org/obo/","rdf":"http://www.w3.org/1999/02/22-rdf-syntax-ns#","owl":"http://www.w3.org/2002/07/owl#","rdfs":"http://www.w3.org/2000/01/rdf-schema#","skos":"http://www.w3.org/2004/02/skos/core#","oboinowl_gen":"http://www.geneontology.org/formats/oboInOwl#","ns0":"http://purl.obolibrary.org/obo/chebi#","metadata_def":"http://data.bioontology.org/metadata/def/","ns1":"http://purl.obolibrary.org/obo/chebi/"},"@graph":[{"@id":"obo_purl:CHEBI_17650","@type":"owl:Class","rdfs:subClassOf":[{"@id":"obo_purl:CHEBI_24261"},{"@id":"obo_purl:CHEBI_47909"},{"@id":"obo_purl:CHEBI_138141"},{"@id":"obo_purl:CHEBI_139590"},{"@id":"obo_purl:CHEBI_139592"},{"@id":"obo_purl:CHEBI_35344"},{"@id":"obo_purl:CHEBI_35346"},{"@id":"obo_purl:CHEBI_36885"}],"rdfs:label":"cortisol","skos:notation":"CHEBI:17650","obo_purl:IAO_0000115":"A 17alpha-hydroxy-C21-steroid that is pregn-4-ene substituted by oxo groups at positions 3 and 20 and hydroxy groups at positions 11, 17 and 21. Cortisol is a corticosteroid hormone or glucocorticoid produced by zona fasciculata of the adrenal cortex, which is a part of the adrenal gland. It is usually referred to as the \"stress hormone\" as it is involved in response to stress and anxiety, controlled by corticotropin-releasing hormone (CRH). It increases blood pressure and blood sugar, and reduces immune responses","oboinowl_gen:hasExactSynonym":["cortisol","11beta,17,21-trihydroxypregn-4-ene-3,20-dione","Cortisol"],"oboinowl_gen:hasDbXref":["Beilstein:1354819","CAS:50-23-7","DrugBank:DB00741","Drug_Central:1388","KEGG:C00735","KEGG:D00088","LINCS:LSM-5980","LIPID_MAPS_instance:LMST02030001","PDBeChem:HCY","PMID:10438974","PMID:2268561","Patent:US2602769","Wikipedia:Hydrocortisone"],"oboinowl_gen:hasOBONamespace":"chebi_ontology","oboinowl_gen:id":"CHEBI:17650","oboinowl_gen:inSubset":{"@id":"ns0:3_STAR"},"ns0:has_parent_hydride":{"@id":"obo_purl:CHEBI_8386"},"metadata_def:prefLabel":"cortisol","oboinowl_gen:hasRelatedSynonym":["(11beta)-11,17,21-trihydroxypregn-4-ene-3,20-dione","11beta,17alpha,21-Trihydroxy-4-pregnene-3,20-dione","11beta,17alpha,21-trihydroxy-4-pregnene-3,20-dione","11beta-hydrocortisone","17-hydroxycorticosterone","4-pregnen-11beta,17alpha,21-triol-3,20-dione","Hydrocortisone","Kendall's compound F","Reichstein's substance M","hidrocortisona","hydrocortisone","hydrocortisonum"],"metadata_def:mappingLoom":"cortisol","metadata_def:mappingSameURI":{"@id":"obo_purl:CHEBI_17650"},"oboinowl_gen:hasAlternativeId":["CHEBI:14023","CHEBI:24633","CHEBI:3893","CHEBI:58221"],"obo_purl:RO_0000087":[{"@id":"obo_purl:CHEBI_88188"},{"@id":"obo_purl:CHEBI_35472"},{"@id":"obo_purl:CHEBI_49167"},{"@id":"obo_purl:CHEBI_50857"},{"@id":"obo_purl:CHEBI_75771"},{"@id":"obo_purl:CHEBI_77746"}],"ns1:charge":"0","ns1:formula":"C21H30O5","ns1:inchi":"InChI=1S/C21H30O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-16,18,22,24,26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1","ns1:inchikey":"JYGXADMDTFJGBT-VWUMJDOOSA-N","ns1:mass":"362.45990","ns1:monoisotopicmass":"362.20932","ns1:smiles":"[H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])[C@@H](O)C[C@@]1(C)[C@@]2([H])CC[C@]1(O)C(=O)CO"},{"@id":"obo_purl:ECTO_9000297","obo_purl:RO_0002309":{"@id":"obo_purl:CHEBI_17650"}}]}