<?xml version="1.0" encoding="UTF-8"?> <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:obo_purl="http://purl.obolibrary.org/obo/" xmlns:owl="http://www.w3.org/2002/07/owl#" xmlns:rdfs="http://www.w3.org/2000/01/rdf-schema#" xmlns:skos="http://www.w3.org/2004/02/skos/core#" xmlns:oboinowl_gen="http://www.geneontology.org/formats/oboInOwl#" xmlns:metadata_def="http://data.bioontology.org/metadata/def/"> <owl:Class rdf:about="http://purl.obolibrary.org/obo/PR_000030035"> <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000004"/> <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000040"/> <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PR_000000001"/> <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_36080"/> <rdfs:label>G-protein coupled receptor</rdfs:label> <rdfs:comment>Category=family. Classification based on GRAFS system. [PMID:12761335]</rdfs:comment> <skos:notation>PR:000030035</skos:notation> <obo_purl:IAO_0000115>A protein that has G protein-coupled receptor (GPCR) activity. Each GPCR consists of a single polypeptide with an extracellular N-terminus, an intracellular C-terminus and seven hydrophobic transmembrane domains (TM1-TM7) linked by three extracellular loops (ECL1-ECL3) and three intracellular loops (ICL1-ICL3). GPCRs function as part of a heterotrimeric complex to transmit an extracellular signal across the membrane by activating an associated G-protein via the exchange of GDP for GTP on the alpha subunit.</obo_purl:IAO_0000115> <oboinowl_gen:hasExactSynonym>fam:GPCR</oboinowl_gen:hasExactSynonym> <oboinowl_gen:hasDbXref>IUPHARfam:694</oboinowl_gen:hasDbXref> <oboinowl_gen:hasOBONamespace>protein</oboinowl_gen:hasOBONamespace> <oboinowl_gen:id>PR:000030035</oboinowl_gen:id> <metadata_def:prefLabel>G-protein coupled receptor</metadata_def:prefLabel> <oboinowl_gen:hasBroadSynonym>7TM receptor</oboinowl_gen:hasBroadSynonym> <oboinowl_gen:hasBroadSynonym>seven-transmembrane receptor</oboinowl_gen:hasBroadSynonym> <metadata_def:mappingLoom>gproteincoupledreceptor</metadata_def:mappingLoom> <metadata_def:mappingSameURI rdf:resource="http://purl.obolibrary.org/obo/PR_000030035"/> <obo_purl:RO_0002215 rdf:resource="http://purl.obolibrary.org/obo/GO_0004930"/> </owl:Class> <rdf:Description rdf:about="http://purl.obolibrary.org/obo/PR_000001087"> <rdfs:subClassOf> <rdf:Description rdf:about="http://purl.obolibrary.org/obo/PR_000030035"> <metadata_def:mappingSameURI rdf:resource="http://purl.obolibrary.org/obo/PR_000030035"/> </rdf:Description> </rdfs:subClassOf> </rdf:Description> <rdf:Description rdf:about="http://purl.obolibrary.org/obo/PR_000001094"> <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PR_000030035"/> </rdf:Description> </rdf:RDF>