{"@context":{"obo_purl":"http://purl.obolibrary.org/obo/","rdf":"http://www.w3.org/1999/02/22-rdf-syntax-ns#","owl":"http://www.w3.org/2002/07/owl#","rdfs":"http://www.w3.org/2000/01/rdf-schema#","skos":"http://www.w3.org/2004/02/skos/core#","oboinowl_gen":"http://www.geneontology.org/formats/oboInOwl#","metadata_def":"http://data.bioontology.org/metadata/def/"},"@graph":[{"@id":"obo_purl:GO_0002460","@type":"owl:Class","rdfs:subClassOf":{"@id":"obo_purl:GO_0002250"},"rdfs:label":"adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains","skos:notation":"GO:0002460","obo_purl:IAO_0000115":"An immune response mediated by lymphocytes expressing specific receptors for antigen produced through a somatic diversification process that includes somatic recombination of germline gene segments encoding immunoglobulin superfamily domains. Recombined receptors for antigen encoded by immunoglobulin superfamily domains include T cell receptors and immunoglobulins (antibodies) produced by B cells. The first encounter with antigen elicits a primary immune response that is slow and not of great magnitude. T and B cells selected by antigen become activated and undergo clonal expansion. A fraction of antigen-reactive T and B cells become memory cells, whereas others differentiate into effector cells. The memory cells generated during the primary response enable a much faster and stronger secondary immune response upon subsequent exposures to the same antigen (immunological memory). An example of this is the adaptive immune response found in Mus musculus.","oboinowl_gen:hasOBONamespace":"biological_process","oboinowl_gen:id":"GO:0002460","metadata_def:prefLabel":"adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains","metadata_def:mappingLoom":"adaptiveimmuneresponsebasedonsomaticrecombinationofimmunereceptorsbuiltfromimmunoglobulinsuperfamilydomains","metadata_def:mappingSameURI":{"@id":"obo_purl:GO_0002460"}},{"@id":"obo_purl:GO_0002456","rdfs:subClassOf":{"@id":"obo_purl:GO_0002460"}},{"@id":"obo_purl:GO_0002461","rdfs:subClassOf":{"@id":"obo_purl:GO_0002460"}},{"@id":"obo_purl:GO_0002467","rdfs:subClassOf":{"@id":"obo_purl:GO_0002460"}},{"@id":"obo_purl:GO_0019724","rdfs:subClassOf":{"@id":"obo_purl:GO_0002460"}},{"@id":"obo_purl:GO_0042088","rdfs:subClassOf":{"@id":"obo_purl:GO_0002460"}},{"@id":"obo_purl:GO_0072538","rdfs:subClassOf":{"@id":"obo_purl:GO_0002460"}},{"@id":"obo_purl:GO_0002822","obo_purl:RO_0002211":{"@id":"obo_purl:GO_0002460"}},{"@id":"obo_purl:GO_0002823","obo_purl:RO_0002212":{"@id":"obo_purl:GO_0002460"}},{"@id":"obo_purl:GO_0002824","obo_purl:RO_0002213":{"@id":"obo_purl:GO_0002460"}}]}