{"@context":{"obo_purl":"http://purl.obolibrary.org/obo/","rdf":"http://www.w3.org/1999/02/22-rdf-syntax-ns#","owl":"http://www.w3.org/2002/07/owl#","rdfs":"http://www.w3.org/2000/01/rdf-schema#","oboinowl_gen":"http://www.geneontology.org/formats/oboInOwl#","ns0":"http://purl.obolibrary.org/obo/cl#","ns1":"http://purl.obolibrary.org/obo/uberon/core#","dct":"http://purl.org/dc/terms/","metadata_def":"http://data.bioontology.org/metadata/def/","metadata":"http://data.bioontology.org/metadata/"},"@id":"obo_purl:CL_1001099","@type":"owl:Class","rdfs:subClassOf":[{"@id":"obo_purl:CL_0000115"},{"@id":"obo_purl:CL_1000412"},{"@id":"obo_purl:CL_1001009"}],"rdfs:label":"kidney efferent arteriole endothelial cell","obo_purl:IAO_0000115":"Any endothelial cell that is part of some renal efferent arteriole.","oboinowl_gen:hasDbXref":["https://cellxgene.cziscience.com/cellguide/CL_1001099","KUPO:0001042"],"oboinowl_gen:inSubset":[{"@id":"ns0:human_subset"},{"@id":"ns0:mouse_subset"},{"@id":"ns0:cellxgene_subset"},{"@id":"ns1:human_reference_atlas"}],"dct:description":"Kidney efferent arteriole endothelial cells constitute a vital component of the kidney's microvascular system. They are unique endothelial cells found lining the walls of efferent arterioles, which transport blood away from the glomeruli in the kidney.\nThe primary responsibilities of the kidney efferent arteriole endothelial cells involve controling renal blood flow, regulating glomerular filtration rate (GFR), and managing perfusion pressure. They do this by contracting and relaxing, effectively narrowing and widening the arteriole's lumen thereby controling the volume and rate of blood flow to the peritubular capillaries and creating the pressure gradient necessary for filtration in the glomerulus. \nFurthermore, kidney efferent arteriole endothelial cells show a high degree of plasticity in response to pathophysiological stimuli and can undergo structural and functional changes based on local needs. In conditions like hypertension and diabetes, these cells can experience hypertrophy and endothelial dysfunction, contributing to the progression of renal disease.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)","metadata:def/prefLabel":"kidney efferent arteriole endothelial cell","metadata:def/mappingLoom":"kidneyefferentarterioleendothelialcell","metadata:def/mappingSameURI":{"@id":"obo_purl:CL_1001099"},"metadata:prefixIRI":"CL:1001099","obo_purl:RO_0002175":{"@id":"obo_purl:NCBITaxon_9606"}}