@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix obo_purl: <http://purl.obolibrary.org/obo/> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix oboinowl_gen: <http://www.geneontology.org/formats/oboInOwl#> .
@prefix ns0: <http://purl.obolibrary.org/obo/cl#> .
@prefix ns1: <http://purl.obolibrary.org/obo/uberon/core#> .
@prefix metadata_def: <http://data.bioontology.org/metadata/def/> .
@prefix ns2: <http://data.bioontology.org/rest_backup_mappings/> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix metadata: <http://data.bioontology.org/metadata/> .
@prefix ns3: <http://data.bioontology.org/metadata/obo/> .
obo_purl:CL_0002542
obo_purl:IAO_0100001 obo_purl:CL_1000413 .
obo_purl:CL_0002544
rdfs:subClassOf obo_purl:CL_1000413 .
obo_purl:CL_1000413
metadata_def:mappingLoom "endothelialcellofartery" ;
metadata_def:mappingRest <http://data.bioontology.org/rest_backup_mappings/24360730-b2b1-0136-951d-525400026749>, ns2:a8d24fb0-b2b2-0136-96d3-525400026749 ;
metadata_def:mappingSameURI obo_purl:CL_1000413 ;
metadata_def:prefLabel "endothelial cell of artery" ;
ns3:part_of obo_purl:UBERON_0001917 ;
metadata:prefixIRI "CL:1000413" ;
metadata:treeView obo_purl:UBERON_0001917 ;
obo_purl:IAO_0000115 "A blood vessel endothelial cell that is part of an arterial endothelium." ;
obo_purl:RO_0002175 obo_purl:NCBITaxon_9606 ;
dct:description """Endothelial cells of the artery, also referred to as arterial endothelial cells, form an integral part of the arterial system. They form a single layer, known as the endothelium, lining the interior surface of arteries, and are able to respond to the high-pressure and flow conditions present in arteries. The primary role of these cells is to provide a barrier between the vessel wall and the blood, exhibiting selective permeability to regulate the movement of liquids, gases, and blood-borne substances across the vascular wall.
Arterial endothelial cells significantly contribute to maintaining vascular homeostasis. They are at the forefront of sensations and responses to mechanical stimuli, like shear stress and blood pressure changes. An additional key function pertains to the production of nitric oxide, which helps to regulate vascular tone and blood pressure, prevents platelet aggregation, limits leukocyte adhesion to the endothelium, and inhibits smooth muscle cell proliferation. These varied but connected functions help to preclude the development of atherosclerosis, ensuring normal circulation and arterial health.
Moreover, these cells play a pivotal role in inflammation and coagulation processes. During inflammatory events, they express various adhesion molecules, aiding in leukocyte recruitment and rolling onto the vessel walls for immune response. They also produce anticoagulant and procoagulant substances, involved in blood clotting and clot dissolution, respectively. Dysregulation of the usual functions of arterial endothelial cells can result in serious pathophysiological conditions, such as atherosclerosis, hypertension, and other cardiovascular diseases.
(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ;
oboinowl_gen:hasDbXref "BTO:0004758", "FMA:67761", "KUPO:0001095" ;
oboinowl_gen:hasExactSynonym "arterial endothelial cell" ;
oboinowl_gen:inSubset ns0:cellxgene_subset, ns0:human_subset, ns0:mouse_subset, ns1:human_reference_atlas ;
a owl:Class ;
rdfs:label "endothelial cell of artery" ;
rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1000413" ;
rdfs:subClassOf obo_purl:CL_0000071, obo_purl:CL_0000115 .
obo_purl:CL_1001213
rdfs:subClassOf obo_purl:CL_1000413 .
obo_purl:CL_1001216
rdfs:subClassOf obo_purl:CL_1000413 .
obo_purl:CL_1001568
rdfs:subClassOf obo_purl:CL_1000413 .
obo_purl:CL_2000018
rdfs:subClassOf obo_purl:CL_1000413 .
obo_purl:CL_2000052
rdfs:subClassOf obo_purl:CL_1000413 .
obo_purl:CL_4047006
rdfs:subClassOf obo_purl:CL_1000413 .
obo_purl:GO_0060842
obo_purl:RO_0002315 obo_purl:CL_1000413 .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix obo_purl: <http://purl.obolibrary.org/obo/> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix oboinowl_gen: <http://www.geneontology.org/formats/oboInOwl#> .
@prefix ns0: <http://purl.obolibrary.org/obo/cl#> .
@prefix ns1: <http://purl.obolibrary.org/obo/uberon/core#> .
@prefix metadata_def: <http://data.bioontology.org/metadata/def/> .
@prefix ns2: <http://data.bioontology.org/rest_backup_mappings/> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix metadata: <http://data.bioontology.org/metadata/> .
@prefix ns3: <http://data.bioontology.org/metadata/obo/> .
obo_purl:CL_0002542
obo_purl:IAO_0100001 obo_purl:CL_1000413 .
obo_purl:CL_0002544
rdfs:subClassOf obo_purl:CL_1000413 .
obo_purl:CL_1000413
metadata_def:mappingLoom "endothelialcellofartery" ;
metadata_def:mappingRest <http://data.bioontology.org/rest_backup_mappings/24360730-b2b1-0136-951d-525400026749>, ns2:a8d24fb0-b2b2-0136-96d3-525400026749 ;
metadata_def:mappingSameURI obo_purl:CL_1000413 ;
metadata_def:prefLabel "endothelial cell of artery" ;
ns3:part_of obo_purl:UBERON_0001917 ;
metadata:prefixIRI "CL:1000413" ;
metadata:treeView obo_purl:UBERON_0001917 ;
obo_purl:IAO_0000115 "A blood vessel endothelial cell that is part of an arterial endothelium." ;
obo_purl:RO_0002175 obo_purl:NCBITaxon_9606 ;
dct:description """Endothelial cells of the artery, also referred to as arterial endothelial cells, form an integral part of the arterial system. They form a single layer, known as the endothelium, lining the interior surface of arteries, and are able to respond to the high-pressure and flow conditions present in arteries. The primary role of these cells is to provide a barrier between the vessel wall and the blood, exhibiting selective permeability to regulate the movement of liquids, gases, and blood-borne substances across the vascular wall.
Arterial endothelial cells significantly contribute to maintaining vascular homeostasis. They are at the forefront of sensations and responses to mechanical stimuli, like shear stress and blood pressure changes. An additional key function pertains to the production of nitric oxide, which helps to regulate vascular tone and blood pressure, prevents platelet aggregation, limits leukocyte adhesion to the endothelium, and inhibits smooth muscle cell proliferation. These varied but connected functions help to preclude the development of atherosclerosis, ensuring normal circulation and arterial health.
Moreover, these cells play a pivotal role in inflammation and coagulation processes. During inflammatory events, they express various adhesion molecules, aiding in leukocyte recruitment and rolling onto the vessel walls for immune response. They also produce anticoagulant and procoagulant substances, involved in blood clotting and clot dissolution, respectively. Dysregulation of the usual functions of arterial endothelial cells can result in serious pathophysiological conditions, such as atherosclerosis, hypertension, and other cardiovascular diseases.
(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ;
oboinowl_gen:hasDbXref "BTO:0004758", "FMA:67761", "KUPO:0001095" ;
oboinowl_gen:hasExactSynonym "arterial endothelial cell" ;
oboinowl_gen:inSubset ns0:cellxgene_subset, ns0:human_subset, ns0:mouse_subset, ns1:human_reference_atlas ;
a owl:Class ;
rdfs:label "endothelial cell of artery" ;
rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_1000413" ;
rdfs:subClassOf obo_purl:CL_0000071, obo_purl:CL_0000115 .
obo_purl:CL_1001213
rdfs:subClassOf obo_purl:CL_1000413 .
obo_purl:CL_1001216
rdfs:subClassOf obo_purl:CL_1000413 .
obo_purl:CL_1001568
rdfs:subClassOf obo_purl:CL_1000413 .
obo_purl:CL_2000018
rdfs:subClassOf obo_purl:CL_1000413 .
obo_purl:CL_2000052
rdfs:subClassOf obo_purl:CL_1000413 .
obo_purl:CL_4047006
rdfs:subClassOf obo_purl:CL_1000413 .
obo_purl:GO_0060842
obo_purl:RO_0002315 obo_purl:CL_1000413 .