{"@context":{"obo_purl":"http://purl.obolibrary.org/obo/","rdf":"http://www.w3.org/1999/02/22-rdf-syntax-ns#","owl":"http://www.w3.org/2002/07/owl#","rdfs":"http://www.w3.org/2000/01/rdf-schema#","oboinowl_gen":"http://www.geneontology.org/formats/oboInOwl#","ns0":"http://purl.obolibrary.org/obo/cl#","metadata_def":"http://data.bioontology.org/metadata/def/","ns1":"http://data.bioontology.org/rest_backup_mappings/","dct":"http://purl.org/dc/terms/","ns2":"https://orcid.org/","metadata":"http://data.bioontology.org/metadata/"},"@graph":[{"@id":"obo_purl:CL_0002139","@type":"owl:Class","rdfs:subClassOf":{"@id":"obo_purl:CL_0000115"},"rdfs:label":"endothelial cell of vascular tree","rdfs:comment":"These cells are reportedly CD31-positive, CD34-positive, CD144-positive, TAL1-positive.","obo_purl:IAO_0000115":"An endothelial cell of the vascular tree, which includes blood vessels and lymphatic vessels.","oboinowl_gen:hasExactSynonym":"vascular endothelial cell","oboinowl_gen:creation_date":{"@type":"http://www.w3.org/2001/XMLSchema#dateTime","@value":"2010-08-24T02:06:40Z"},"oboinowl_gen:hasDbXref":["https://cellxgene.cziscience.com/cellguide/CL_0002139","BTO:0001854","CALOHA:TS-1106","FMA:67755"],"oboinowl_gen:inSubset":[{"@id":"ns0:human_subset"},{"@id":"ns0:mouse_subset"},{"@id":"ns0:cellxgene_subset"}],"metadata:def/mappingRest":[{"@id":"ns1:b80b9030-b2b3-0136-9807-525400026749"},{"@id":"ns1:ec365ad0-be45-0136-e70e-525400026749"},{"@id":"ns1:4a16e030-b2b0-0136-9423-525400026749"}],"dct:contributor":{"@id":"ns2:0000-0003-1980-3228"},"dct:description":"Endothelial cells of the vascular tree, commonly referred to as vascular endothelial cells, line the entire circulatory system, from the heart to the smallest capillaries. These cells have a unique, flattened shape, and are tightly bound together, forming a thin layer known as the endothelium. The endothelium is responsible for maintaining the interior surface of blood vessels, and plays a critical role in ensuring the smooth flow of blood. \nVascular endothelial cells act as a semi-permeable membrane, controlling the passage of materials and the transit of white blood cells into and out of the bloodstream. These cells are also involved in blood coagulation. When a blood vessel is damaged, endothelial cells promote clotting to prevent excessive bleeding and facilitate wound healing. Other functions include regulation of blood pressure and blood volume by releasing vasodilators and vasoconstrictors to either widen or constrict blood vessels, accordingly.\nFurthermore, the endothelial cells are crucial in the formation of new blood vessels, a process known as angiogenesis. This is particularly important in wound healing and the growth of new tissues during development or after injury. In the context of diseases such as cancer, angiogenesis helps facilitate tumor growth by providing nutrients and oxygen.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)","metadata:def/prefLabel":"endothelial cell of vascular tree","oboinowl_gen:hasNarrowSynonym":"cubodial endothelial cell of vascular tree","metadata:def/mappingLoom":"endothelialcellofvasculartree","metadata:def/mappingSameURI":{"@id":"obo_purl:CL_0002139"},"metadata:prefixIRI":"CL:0002139"},{"@id":"obo_purl:CL_0002138","rdfs:subClassOf":{"@id":"obo_purl:CL_0002139"}},{"@id":"obo_purl:CL_0000071","rdfs:subClassOf":{"@id":"obo_purl:CL_0002139"}},{"@id":"obo_purl:CL_1000414","rdfs:subClassOf":{"@id":"obo_purl:CL_0002139"}},{"@id":"obo_purl:CL_1001567","rdfs:subClassOf":{"@id":"obo_purl:CL_0002139"}},{"@id":"obo_purl:CL_1001568","rdfs:subClassOf":{"@id":"obo_purl:CL_0002139"}},{"@id":"obo_purl:CL_0002652","rdfs:subClassOf":{"@id":"obo_purl:CL_0002139"}}]}