@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix obo_purl: <http://purl.obolibrary.org/obo/> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix oboinowl_gen: <http://www.geneontology.org/formats/oboInOwl#> .
@prefix ns0: <http://purl.obolibrary.org/obo/cl#> .
@prefix metadata_def: <http://data.bioontology.org/metadata/def/> .
@prefix ns1: <http://data.bioontology.org/rest_backup_mappings/> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix metadata: <http://data.bioontology.org/metadata/> .
@prefix ns2: <http://data.bioontology.org/metadata/obo/> .
obo_purl:CL_0000078
rdfs:subClassOf obo_purl:CL_0000362 .
obo_purl:CL_0000317
rdfs:subClassOf obo_purl:CL_0000362 .
obo_purl:CL_0000362
metadata_def:mappingLoom "epidermalcell" ;
metadata_def:mappingRest <http://data.bioontology.org/rest_backup_mappings/14869d30-b2b4-0136-9883-525400026749>, ns1:bf9aa1d0-b2b4-0136-991b-525400026749 ;
metadata_def:mappingSameURI obo_purl:CL_0000362 ;
metadata_def:prefLabel "epidermal cell" ;
ns2:part_of obo_purl:UBERON_0007376 ;
metadata:prefixIRI "CL:0000362" ;
metadata:treeView obo_purl:UBERON_0007376 ;
obo_purl:IAO_0000115 "An epithelial cell of the integument (the outer layer of an organism)." ;
dct:description """Epidermal cells constitute the outermost layer of the skin in animals and have a multifaceted role in maintaining the body's overall homeostasis. They originate from the ectoderm and form the epidermis, a stratified squamous epithelium that mostly consists of keratinocytes in various stages of differentiation. The primary role of these cells is to act as a physical barrier, shielding the internal organs, tissues, and system from dehydration, infection, and other external influences such as UV radiation. The thickness and stratification of the epidermis vary with its location in the body, depending on the specific demand for protective function.
One notable characteristic of epidermal cells is their continuous cycle of renewal. The cells are produced in the deepest layer of the epidermis, known as the basal or germinative layer, where they undergo cell division. As new cells form, they gradually push the older cells towards the skin surface. While ascending, these cells undergo a process known as keratinization, where they become filled with keratin, a protein that provides strength and rigidity. By the time they reach the surface, they are essentially dead and filled with keratin, forming a tough, resistant layer that is regularly shed and replaced by newer cells beneath. This entire process, from cell generation to shedding, usually takes around a month.
(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ;
oboinowl_gen:hasDbXref "BTO:0001470", "CALOHA:TS-0283", "FMA:62411", "MESH:D000078404", "ZFA:0009183" ;
oboinowl_gen:hasExactSynonym "cell of epidermis" ;
oboinowl_gen:hasNarrowSynonym "epithelial cell of skin" ;
oboinowl_gen:inSubset ns0:cellxgene_subset, ns0:human_subset, ns0:mouse_subset ;
a owl:Class ;
rdfs:label "epidermal cell" ;
rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000362" ;
rdfs:subClassOf obo_purl:CL_0000066, obo_purl:CL_0002159 .
obo_purl:CL_0000463
rdfs:subClassOf obo_purl:CL_0000362 .
obo_purl:CL_0000712
rdfs:subClassOf obo_purl:CL_0000362 .
obo_purl:CL_0002135
rdfs:subClassOf obo_purl:CL_0000362 .
obo_purl:CL_0002560
rdfs:subClassOf obo_purl:CL_0000362 .
obo_purl:CL_0002561
rdfs:subClassOf obo_purl:CL_0000362 .
obo_purl:CL_0002562
rdfs:subClassOf obo_purl:CL_0000362 .
obo_purl:CL_1000396
obo_purl:IAO_0100001 obo_purl:CL_0000362 .
obo_purl:CL_1000448
rdfs:subClassOf obo_purl:CL_0000362 .
obo_purl:CL_4052058
rdfs:subClassOf obo_purl:CL_0000362 .
obo_purl:CL_4052061
rdfs:subClassOf obo_purl:CL_0000362 .
obo_purl:GO_0009913
obo_purl:RO_0002315 obo_purl:CL_0000362 .
obo_purl:GO_0010481
obo_purl:RO_0004009 obo_purl:CL_0000362 .
obo_purl:GO_0031424
obo_purl:BFO_0000066 obo_purl:CL_0000362 .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix obo_purl: <http://purl.obolibrary.org/obo/> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix oboinowl_gen: <http://www.geneontology.org/formats/oboInOwl#> .
@prefix ns0: <http://purl.obolibrary.org/obo/cl#> .
@prefix metadata_def: <http://data.bioontology.org/metadata/def/> .
@prefix ns1: <http://data.bioontology.org/rest_backup_mappings/> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix metadata: <http://data.bioontology.org/metadata/> .
@prefix ns2: <http://data.bioontology.org/metadata/obo/> .
obo_purl:CL_0000078
rdfs:subClassOf obo_purl:CL_0000362 .
obo_purl:CL_0000317
rdfs:subClassOf obo_purl:CL_0000362 .
obo_purl:CL_0000362
metadata_def:mappingLoom "epidermalcell" ;
metadata_def:mappingRest <http://data.bioontology.org/rest_backup_mappings/14869d30-b2b4-0136-9883-525400026749>, ns1:bf9aa1d0-b2b4-0136-991b-525400026749 ;
metadata_def:mappingSameURI obo_purl:CL_0000362 ;
metadata_def:prefLabel "epidermal cell" ;
ns2:part_of obo_purl:UBERON_0007376 ;
metadata:prefixIRI "CL:0000362" ;
metadata:treeView obo_purl:UBERON_0007376 ;
obo_purl:IAO_0000115 "An epithelial cell of the integument (the outer layer of an organism)." ;
dct:description """Epidermal cells constitute the outermost layer of the skin in animals and have a multifaceted role in maintaining the body's overall homeostasis. They originate from the ectoderm and form the epidermis, a stratified squamous epithelium that mostly consists of keratinocytes in various stages of differentiation. The primary role of these cells is to act as a physical barrier, shielding the internal organs, tissues, and system from dehydration, infection, and other external influences such as UV radiation. The thickness and stratification of the epidermis vary with its location in the body, depending on the specific demand for protective function.
One notable characteristic of epidermal cells is their continuous cycle of renewal. The cells are produced in the deepest layer of the epidermis, known as the basal or germinative layer, where they undergo cell division. As new cells form, they gradually push the older cells towards the skin surface. While ascending, these cells undergo a process known as keratinization, where they become filled with keratin, a protein that provides strength and rigidity. By the time they reach the surface, they are essentially dead and filled with keratin, forming a tough, resistant layer that is regularly shed and replaced by newer cells beneath. This entire process, from cell generation to shedding, usually takes around a month.
(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)""" ;
oboinowl_gen:hasDbXref "BTO:0001470", "CALOHA:TS-0283", "FMA:62411", "MESH:D000078404", "ZFA:0009183" ;
oboinowl_gen:hasExactSynonym "cell of epidermis" ;
oboinowl_gen:hasNarrowSynonym "epithelial cell of skin" ;
oboinowl_gen:inSubset ns0:cellxgene_subset, ns0:human_subset, ns0:mouse_subset ;
a owl:Class ;
rdfs:label "epidermal cell" ;
rdfs:seeAlso "https://cellxgene.cziscience.com/cellguide/CL_0000362" ;
rdfs:subClassOf obo_purl:CL_0000066, obo_purl:CL_0002159 .
obo_purl:CL_0000463
rdfs:subClassOf obo_purl:CL_0000362 .
obo_purl:CL_0000712
rdfs:subClassOf obo_purl:CL_0000362 .
obo_purl:CL_0002135
rdfs:subClassOf obo_purl:CL_0000362 .
obo_purl:CL_0002560
rdfs:subClassOf obo_purl:CL_0000362 .
obo_purl:CL_0002561
rdfs:subClassOf obo_purl:CL_0000362 .
obo_purl:CL_0002562
rdfs:subClassOf obo_purl:CL_0000362 .
obo_purl:CL_1000396
obo_purl:IAO_0100001 obo_purl:CL_0000362 .
obo_purl:CL_1000448
rdfs:subClassOf obo_purl:CL_0000362 .
obo_purl:CL_4052058
rdfs:subClassOf obo_purl:CL_0000362 .
obo_purl:CL_4052061
rdfs:subClassOf obo_purl:CL_0000362 .
obo_purl:GO_0009913
obo_purl:RO_0002315 obo_purl:CL_0000362 .
obo_purl:GO_0010481
obo_purl:RO_0004009 obo_purl:CL_0000362 .
obo_purl:GO_0031424
obo_purl:BFO_0000066 obo_purl:CL_0000362 .