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ID	http://purl.obolibrary.org/obo/PR_000000680 http://purl.obolibrary.org/obo/PR_000000680 Loading
Preferred name	transient receptor potential cation channel TRPC
Synonyms	fam:TRPC
Definitions	A transient receptor potential channel protein that is a member of the subfamily C of the transient receptor potential cation channels (TRPs), with amino- and carboxyl-terminal intracellular domains separated by a domain (common with other ion channels) containing six transmembrane helices (S1-S6) in which the last two helices (S5 and S6) flank a loop, called the pore loop, which determines ion selectivity. The amino-terminal domain contains up to 4 detectable copies of Ankyrin repeat (Pfam:PF00023) followed by the Transient receptor ion channel II domain (Pfam:PF08344). Most TRPs are relatively non-selective. They may be modulated by voltage changes but channel gating is generally effected by other means.

rdfs:comment	Category=family.
rdfs:comment	Category=family.
oboinowl_gen:hasDbXref	PIRSF:PIRSF005528
obo_purl:IAO_0000115	A transient receptor potential channel protein that is a member of the subfamily C of the transient receptor potential cation channels (TRPs), with amino- and carboxyl-terminal intracellular domains separated by a domain (common with other ion channels) containing six transmembrane helices (S1-S6) in which the last two helices (S5 and S6) flank a loop, called the pore loop, which determines ion selectivity. The amino-terminal domain contains up to 4 detectable copies of Ankyrin repeat (Pfam:PF00023) followed by the Transient receptor ion channel II domain (Pfam:PF08344). Most TRPs are relatively non-selective. They may be modulated by voltage changes but channel gating is generally effected by other means.
skos:notation	PR:000000680
oboinowl_gen:hasExactSynonym	fam:TRPC
oboinowl_gen:hasOBONamespace	protein
rdf:type	http://www.w3.org/2002/07/owl#Class
oboinowl_gen:id	PR:000000680
rdfs:label	transient receptor potential cation channel TRPC
rdfs:subClassOf	http://purl.obolibrary.org/obo/PR_000044657

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