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ID	http://purl.obolibrary.org/obo/CHEBI_50276 http://purl.obolibrary.org/obo/CHEBI_50276 Loading
Preferred name	EC 5.99.1.2 (DNA topoisomerase) inhibitor
Synonyms	EC 5.99.1.2 inhibitor
Definitions	A topoisomerase inhibitor that inhibits the bacterial enzymes of the DNA topoisomerases, Type I class (EC 5.99.1.2) that catalyze ATP-independent breakage of one of the two strands of DNA, passage of the unbroken strand through the break, and rejoining of the broken strand. These bacterial enzymes reduce the topological stress in the DNA structure by relaxing negatively, but not positively, supercoiled DNA.

obo_purl:IAO_0000115	A topoisomerase inhibitor that inhibits the bacterial enzymes of the DNA topoisomerases, Type I class (EC 5.99.1.2) that catalyze ATP-independent breakage of one of the two strands of DNA, passage of the unbroken strand through the break, and rejoining of the broken strand. These bacterial enzymes reduce the topological stress in the DNA structure by relaxing negatively, but not positively, supercoiled DNA.
rdf:type	http://www.w3.org/2002/07/owl#Class
oboinowl_gen:hasRelatedSynonym	EC 5.99.1.2 inhibitor topoisomerase I (EC 5.99.1.2) inhibitors DNA topoisomerase inhibitors EC 5.99.1.2 inhibitors topoisomerase I (EC 5.99.1.2) inhibitor topoisomerase I inhibitor EC 5.99.1.2 (DNA topoisomerase) inhibitors type I DNA topoisomerase inhibitors EC 5.99.1.2 (topoisomerase I) inhibitors type I DNA topoisomerase inhibitor EC 5.99.1.2 (topoisomerase I) inhibitor DNA topoisomerase inhibitor topoisomerase I inhibitors
rdfs:label	EC 5.99.1.2 (DNA topoisomerase) inhibitor
rdfs:subClassOf	http://purl.obolibrary.org/obo/CHEBI_70727

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