Gene Ontology (GO)
OWL
Last submission date April 20, 2024
ID http://purl.obolibrary.org/obo/GO_0061630
http://purl.obolibrary.org/obo/GO_0061630
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Preferred name

ubiquitin protein ligase activity

Synonyms

E3

Definitions

Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues.

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