Experimental Factor Ontology

Last uploaded: July 4, 2019
Preferred Name

spleen

Synonyms

lien

Entire spleen

Definitions

Organ found in virtually all vertebrate animals with important roles in regard to red blood cells and the immune system. In humans, it is located in the left upper quadrant of the abdomen. It removes old red blood cells and holds a reserve in case of hemorrhagic shock, especially in animals like horses (not in humans), while recycling iron. It synthesizes antibodies in its white pulp and removes, from blood and lymph node circulation, antibody-coated bacteria along with antibody-coated blood cells. Taxon notes: Neither hagfish nor lampreys possess what might be considered a discrete and condensed spleen. Hagfish possess dispersed lymphoid tissue within the submucosa of the intestine (96) associated with the portal vein (97), whereas lymphoid tissue is associated with the typhlosole portion of the intestine in lampreys (96) [PMID:20959416] the organ that functions to filter blood and to store red corpuscles and platelets

ID

http://purl.obolibrary.org/obo/UBERON_0002106

comment

Taxon notes: Neither hagfish nor lampreys possess what might be considered a discrete and condensed spleen. Hagfish possess dispersed lymphoid tissue within the submucosa of the intestine (96) associated with the portal vein (97), whereas lymphoid tissue is associated with the typhlosole portion of the intestine in lampreys (96) [PMID:20959416]

database_cross_reference

MSH:D013154

EV:0100055

MIAA:0000085

SNOMEDCT:181279003

UMLS:C0037993

CALOHA:TS-0956

MA:0000141

GAID:1289

Wikipedia:Spleen

MESH:A15.382.520.604.713

NCIT:C12432

http://upload.wikimedia.org/wikipedia/commons/d/d6/Illu_spleen.jpg

OpenCyc:Mx4rvVjgw5wpEbGdrcN5Y29ycA

http://upload.wikimedia.org/wikipedia/commons/thumb/d/d6/Illu_spleen.jpg/200px-Illu_spleen.jpg

VHOG:0000120

galen:Spleen

FMA:7196

EMAPA:18767

MAT:0000085

TAO:0000436

EFO:0000869

XAO:0000328

BTO:0001281

ZFA:0000436

AAO:0010395

NCIt:C12432

http://www.snomedbrowser.com/Codes/Details/181279003

http://en.wikipedia.org/wiki/Spleen

http://linkedlifedata.com/resource/umls/id/C0037993

definition

Organ found in virtually all vertebrate animals with important roles in regard to red blood cells and the immune system. In humans, it is located in the left upper quadrant of the abdomen. It removes old red blood cells and holds a reserve in case of hemorrhagic shock, especially in animals like horses (not in humans), while recycling iron. It synthesizes antibodies in its white pulp and removes, from blood and lymph node circulation, antibody-coated bacteria along with antibody-coated blood cells.

the organ that functions to filter blood and to store red corpuscles and platelets

depicted_by

http://upload.wikimedia.org/wikipedia/commons/d/d6/Illu_spleen.jpg

develops_from

http://purl.obolibrary.org/obo/UBERON_0000945

http://purl.obolibrary.org/obo/UBERON_0003061

http://purl.obolibrary.org/obo/UBERON_0001048

external_definition

An organ involved in red blood cell filtration and immune response.[AAO]

has_exact_synonym

lien

Entire spleen

has_obo_namespace

uberon

has_related_synonym

lien

has_relational_adjective

splenic

lienal

homologous_in

http://purl.obolibrary.org/obo/NCBITaxon_7742

homology_notes

With the advent of clonal selection, the accumulation and segregation of T and B cells in specialized organs for antigen presentation became necessary, and indeed the spleen is found in all jawed vertebrates, but not in agnathans or invertebrates.[well established][VHOG]

id

UBERON:0002106

in_subset

http://purl.obolibrary.org/obo/uberon#efo_slim

http://purl.obolibrary.org/obo/uberon#vertebrate_core

http://purl.obolibrary.org/obo/uberon/core#uberon_slim

http://purl.obolibrary.org/obo/uberon/core#organ_slim

http://purl.obolibrary.org/obo/uberon/core#pheno_slim

http://purl.obolibrary.org/obo/uberon/core#efo_slim

http://purl.obolibrary.org/obo/uberon#uberon_slim

http://purl.obolibrary.org/obo/uberon/core#vertebrate_core

http://purl.obolibrary.org/obo/uberon#organ_slim

label

spleen

notation

UBERON:0002106

part_of

http://purl.obolibrary.org/obo/UBERON_0000916

http://purl.obolibrary.org/obo/UBERON_0001007

prefLabel

spleen

taxon_notes

In humans, it is located in the left upper quadrant of the abdomen. It removes old red blood cells and holds a reserve in case of hemorrhagic shock, especially in animals like horses (not in humans), while recycling iron

Neither hagfish nor lampreys possess what might be considered a discrete and condensed spleen. Hagfish possess dispersed lymphoid tissue within the submucosa of the intestine (96) associated with the portal vein (97), whereas lymphoid tissue is associated with the typhlosole portion of the intestine in lampreys (96)

treeView

http://purl.obolibrary.org/obo/UBERON_0000945

http://purl.obolibrary.org/obo/UBERON_0000916

http://purl.obolibrary.org/obo/UBERON_0003061

http://purl.obolibrary.org/obo/UBERON_0001007

http://purl.obolibrary.org/obo/UBERON_0001048

UBPROP_0000009

It synthesizes antibodies in its white pulp and removes, from blood and lymph node circulation, antibody-coated bacteria along with antibody-coated blood cells

subClassOf

http://purl.obolibrary.org/obo/UBERON_0005057

http://purl.obolibrary.org/obo/UBERON_0004177

http://purl.obolibrary.org/obo/UBERON_0017672

http://purl.obolibrary.org/obo/UBERON_0013765

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