Experimental Factor Ontology (EFO)
OWL
Last submission date April 15, 2025
ID http://purl.obolibrary.org/obo/CL_0000127
http://purl.obolibrary.org/obo/CL_0000127
https://agroportal.lirmm.fr/ontologies/EFO/CL_0000127
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Preferred name

astrocyte

Synonyms
astrocytic glia
Definitions
Astrocytes are reportedly CD68-negative, CD121a-positive, CD184-positive, CD192-positive, CRF-positive, EGFR-positive, GFAP-positive, GLUT1-positive, MBP-negative, and NGFR-positive. A class of large neuroglial (macroglial) cells in the central nervous system - the largest and most numerous neuroglial cells in the brain and spinal cord. Astrocytes (from 'star' cells) are irregularly shaped with many long processes, including those with 'end feet' which form the glial (limiting) membrane and directly and indirectly contribute to the blood-brain barrier. They regulate the extracellular ionic and chemical environment, and 'reactive astrocytes' (along with microglia) respond to injury.
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