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ID	http://purl.obolibrary.org/obo/CHEBI_75998 http://purl.obolibrary.org/obo/CHEBI_75998 https://agroportal.lirmm.fr/ontologies/EFO/CHEBI_75998 Loading
Preferred name	trametinib
Synonyms	N-(3-{3-cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydropyrido[4,3-d]pyrimidin-1(2H)-yl}phenyl)acetamide GSK 1120212 JTP 74057 trametinib trametinibum
Definitions	A pyridopyrimidine that is used (as its dimethyl sulfoxide addition compound) for the treatment of patients with unresectable or metastatic melanoma with BRAF V600E or V600K mutations, and who have not received prior BRAF inhibitor treatment.

rdf:type	http://www.w3.org/2002/07/owl#Class Loading
rdfs:subClassOf	http://purl.obolibrary.org/obo/CHEBI_24532 Loading http://purl.obolibrary.org/obo/CHEBI_37622 Loading
rdfs:label	trametinib
skos:notation	CHEBI:75998
obo_purl:IAO_0000115	A pyridopyrimidine that is used (as its dimethyl sulfoxide addition compound) for the treatment of patients with unresectable or metastatic melanoma with BRAF V600E or V600K mutations, and who have not received prior BRAF inhibitor treatment.
oboinowl_gen:hasExactSynonym	N-(3-{3-cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydropyrido[4,3-d]pyrimidin-1(2H)-yl}phenyl)acetamide
oboinowl_gen:hasDbXref	CAS:871700-17-3 Chemspider:9881833 DrugBank:DB08911 Drug_Central:4802 KEGG:D10175 LINCS:LSM-1143 PMCID:PMC7715110 PMID:21523318 PMID:22245957 PMID:23035153 PMID:23237773 PMID:23248257 PMID:23290787 PMID:23432625 PMID:23438367 PMID:23441129 PMID:23533766 PMID:23583440 PMID:23587417 PMID:23649971 PMID:23658559 PMID:23709751 PMID:23807941 PMID:23844038 PMID:23846731 PMID:23893461 PMID:23971497 PMID:23977666 PMID:24055054 PMID:26119340 PMID:33922284 PMID:34034619 PMID:34145930 PMID:34156985 PMID:34282746 PMID:34355652 PMID:34413035 PMID:34421360 PMID:34484797 PMID:34516041 PMID:34590600 PMID:34592184 Patent:WO2005121142 Patent:WO2011038082 Patent:WO2011038085 Patent:WO2011047238 Reaxys:12497153 Wikipedia:Trametinib See more See less
oboinowl_gen:hasOBONamespace	chebi_ontology
oboinowl_gen:id	CHEBI:75998
oboinowl_gen:inSubset	http://purl.obolibrary.org/obo/chebi#3_STAR Loading
oboinowl_gen:hasRelatedSynonym	GSK 1120212 JTP 74057 trametinib trametinibum
obo_purl:charge	0
obo_purl:formula	C26H23FIN5O4
obo_purl:inchi	InChI=1S/C26H23FIN5O4/c1-13-22-21(23(31(3)24(13)35)30-20-10-7-15(28)11-19(20)27)25(36)33(17-8-9-17)26(37)32(22)18-6-4-5-16(12-18)29-14(2)34/h4-7,10-12,17,30H,8-9H2,1-3H3,(H,29,34)
obo_purl:inchikey	LIRYPHYGHXZJBZ-UHFFFAOYSA-N
obo_purl:mass	615.39480
obo_purl:monoisotopicmass	615.07788
obo_purl:smiles	CC(=O)Nc1cccc(c1)-n1c2c(C)c(=O)n(C)c(Nc3ccc(I)cc3F)c2c(=O)n(C2CC2)c1=O

Subject	Author	Type	Created
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