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ID	http://purl.obolibrary.org/obo/CHEBI_52717 http://purl.obolibrary.org/obo/CHEBI_52717 https://agroportal.lirmm.fr/ontologies/EFO/CHEBI_52717 Loading
Preferred name	bortezomib
Synonyms	[(1R)-3-methyl-1-({(2S)-3-phenyl-2-[(pyrazin-2-ylcarbonyl)amino]propanoyl}amino)butyl]boronic acid bortezomib N-[(1R)-1-(dihydroxyboranyl)-3-methylbutyl]-N(alpha)-(pyrazin-2-ylcarbonyl)-L-phenylalaninamide PS 341 PS-341 Velcade N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE See more See less
Definitions	L-Phenylalaninamide substituted at the amide nitrogen by a 1-(dihydroxyboranyl)-3-methylbutyl group and at N(alpha) by a pyrazin-2-ylcarbonyl group. It is a dipeptidyl boronic acid that reversibly inhibits the 26S proteasome.

rdf:type	http://www.w3.org/2002/07/owl#Class Loading
rdfs:subClassOf	http://purl.obolibrary.org/obo/CHEBI_24532 Loading http://purl.obolibrary.org/obo/CHEBI_37622 Loading
rdfs:label	bortezomib
skos:notation	CHEBI:52717
obo_purl:IAO_0000115	L-Phenylalaninamide substituted at the amide nitrogen by a 1-(dihydroxyboranyl)-3-methylbutyl group and at N(alpha) by a pyrazin-2-ylcarbonyl group. It is a dipeptidyl boronic acid that reversibly inhibits the 26S proteasome.
oboinowl_gen:hasExactSynonym	[(1R)-3-methyl-1-({(2S)-3-phenyl-2-[(pyrazin-2-ylcarbonyl)amino]propanoyl}amino)butyl]boronic acid bortezomib N-[(1R)-1-(dihydroxyboranyl)-3-methylbutyl]-N(alpha)-(pyrazin-2-ylcarbonyl)-L-phenylalaninamide
oboinowl_gen:hasDbXref	CAS:179324-69-7 DrugBank:DB00188 Drug_Central:391 KEGG:D03150 LINCS:LSM-6281 NCIt:C1851 PDBeChem:BO2 PMID:18484921 PMID:18980173 PMID:21504411 PMID:21865767 Reaxys:8723817 SNOMEDCT:398907002 SNOMEDCT:407097007 Wikipedia:Bortezomib MESH:C400082 See more See less
oboinowl_gen:hasOBONamespace	chebi_ontology
oboinowl_gen:id	CHEBI:52717
oboinowl_gen:inSubset	http://purl.obolibrary.org/obo/chebi#3_STAR Loading
has_role	http://purl.obolibrary.org/obo/CHEBI_35610 Loading
oboinowl_gen:hasRelatedSynonym	PS 341 PS-341 Velcade bortezomib N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE
oboinowl_gen:hasAlternativeId	CHEBI:41143
obo_purl:charge	0
obo_purl:formula	C19H25BN4O4
obo_purl:inchi	InChI=1S/C19H25BN4O4/c1-13(2)10-17(20(27)28)24-18(25)15(11-14-6-4-3-5-7-14)23-19(26)16-12-21-8-9-22-16/h3-9,12-13,15,17,27-28H,10-11H2,1-2H3,(H,23,26)(H,24,25)/t15-,17-/m0/s1
obo_purl:inchikey	GXJABQQUPOEUTA-RDJZCZTQSA-N
obo_purl:mass	384.23700
obo_purl:monoisotopicmass	384.19689
obo_purl:smiles	CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)c1cnccn1)B(O)O

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