EFO | Classes | AgroPortal

)

ID	http://purl.obolibrary.org/obo/CHEBI_46345 http://purl.obolibrary.org/obo/CHEBI_46345 https://agroportal.lirmm.fr/ontologies/EFO/CHEBI_46345 Loading
Preferred name	5-fluorouracil
Synonyms	5-Fluorouracil 5-fluoropyrimidine-2,4(1H,3H)-dione 5-fluorouracil 5-FU 5-Fluoracil 5-Fluoropyrimidine-2,4-dione Fluorouracil fluorouracil fluorouracilo fluorouracilum See more See less
Definitions	A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.

rdf:type	http://www.w3.org/2002/07/owl#Class Loading
rdfs:subClassOf	http://purl.obolibrary.org/obo/CHEBI_24431 Loading
rdfs:label	5-fluorouracil
skos:notation	CHEBI:46345
obo_purl:IAO_0000115	A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
oboinowl_gen:hasExactSynonym	5-Fluorouracil 5-fluoropyrimidine-2,4(1H,3H)-dione 5-fluorouracil
oboinowl_gen:hasDbXref	PMID:12520460 Beilstein:127172 CAS:51-21-8 DrugBank:DB00544 Drug_Central:26 HMDB:HMDB0014684 KEGG:C07649 KEGG:D00584 LINCS:LSM-4261 PDBeChem:URF PMID:11356943 PMID:14769231 PMID:19023200 Reaxys:127172 Wikipedia:Fluorouracil ChEMBL:468538 ChemIDplus:51-21-8 KEGG COMPOUND:51-21-8 KEGG COMPOUND:C07649 MeSH:D005472 NCIt:C505 SNOMEDCT:3127006 SNOMEDCT:387172005 See more See less
oboinowl_gen:hasOBONamespace	chebi_ontology
oboinowl_gen:id	CHEBI:46345
oboinowl_gen:inSubset	http://purl.obolibrary.org/obo/chebi#3_STAR Loading
has_role	http://purl.obolibrary.org/obo/CHEBI_35221 Loading http://purl.obolibrary.org/obo/CHEBI_35610 Loading http://purl.obolibrary.org/obo/CHEBI_35705 Loading
oboinowl_gen:hasRelatedSynonym	5-FU 5-Fluoracil 5-Fluoropyrimidine-2,4-dione Fluorouracil fluorouracil fluorouracilo fluorouracilum See more See less
oboinowl_gen:hasAlternativeId	CHEBI:2054 CHEBI:46343
obo_purl:charge	0
obo_purl:formula	C4H3FN2O2
obo_purl:inchi	InChI=1S/C4H3FN2O2/c5-2-1-6-4(9)7-3(2)8/h1H,(H2,6,7,8,9)
obo_purl:inchikey	GHASVSINZRGABV-UHFFFAOYSA-N
obo_purl:mass	130.07730
obo_purl:monoisotopicmass	130.01786
obo_purl:smiles	Fc1c[nH]c(=O)[nH]c1=O

Add comment

Add proposal

Subject	Author	Type	Created
No notes to display