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ID	http://purl.obolibrary.org/obo/UBERON_0002106 http://purl.obolibrary.org/obo/UBERON_0002106 Loading
Preferred name	spleen
Synonyms	lien
Definitions	The organ that functions to filter blood and to store red corpuscles and platelets.

obo_purl:RO_0002175	http://purl.obolibrary.org/obo/NCBITaxon_9606
oboinowl_gen:inSubset	http://purl.obolibrary.org/obo/uberon/core#uberon_slim http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas http://purl.obolibrary.org/obo/uberon/core#organ_slim http://purl.obolibrary.org/obo/uberon/core#pheno_slim http://purl.obolibrary.org/obo/uberon/core#efo_slim http://purl.obolibrary.org/obo/uberon/core#vertebrate_core
oboinowl_gen:hasDbXref	galen:Spleen VHOG:0000120 GAID:1289 Wikipedia:Spleen NCIT:C12432 MA:0000141 MESH:D013154 EV:0100055 MIAA:0000085 UMLS:C0037993 CALOHA:TS-0956 ZFA:0000436 AAO:0010395 EFO:0000869 MAT:0000085 SCTID:181279003 TAO:0000436 BTO:0001281 XAO:0000328 FMA:7196 EMAPA:18767
obo_purl:IAO_0000115	The organ that functions to filter blood and to store red corpuscles and platelets.
skos:notation	UBERON:0002106
oboinowl_gen:hasOBONamespace	uberon
rdf:type	http://www.w3.org/2002/07/owl#Class
obo_purl:UBPROP_0000001	An organ involved in red blood cell filtration and immune response.[AAO]
oboinowl_gen:hasRelatedSynonym	lien
oboinowl_gen:id	UBERON:0002106
obo_purl:UBPROP_0000003	With the advent of clonal selection, the accumulation and segregation of T and B cells in specialized organs for antigen presentation became necessary, and indeed the spleen is found in all jawed vertebrates, but not in agnathans or invertebrates.[well established][VHOG]
obo_purl:UBPROP_0000007	splenic lienal
rdfs:label	spleen
obo_purl:UBPROP_0000008	Neither hagfish nor lampreys possess what might be considered a discrete and condensed spleen. Hagfish possess dispersed lymphoid tissue within the submucosa of the intestine (96) associated with the portal vein (97), whereas lymphoid tissue is associated with the typhlosole portion of the intestine in lampreys (96) In humans, it is located in the left upper quadrant of the abdomen. It removes old red blood cells and holds a reserve in case of hemorrhagic shock, especially in animals like horses (not in humans), while recycling iron
foaf:depiction	https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Spleen.glb https://ccf-ontology.hubmapconsortium.org/objects/v1.0/VH_F_Spleen.glb https://upload.wikimedia.org/wikipedia/commons/d/d6/Illu_spleen.jpg https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Spleen.glb
obo_purl:UBPROP_0000009	It synthesizes antibodies in its white pulp and removes, from blood and lymph node circulation, antibody-coated bacteria along with antibody-coated blood cells
rdfs:subClassOf	http://purl.obolibrary.org/obo/UBERON_0005057 http://purl.obolibrary.org/obo/UBERON_0002075

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