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ID	http://purl.obolibrary.org/obo/CHEBI_50276 http://purl.obolibrary.org/obo/CHEBI_50276 Loading
Preferred name	EC 5.99.1.2 (DNA topoisomerase) inhibitor
Synonyms	EC 5.99.1.2 inhibitors
Definitions	A topoisomerase inhibitor that inhibits the bacterial enzymes of the DNA topoisomerases, Type I class (EC 5.99.1.2) that catalyze ATP-independent breakage of one of the two strands of DNA, passage of the unbroken strand through the break, and rejoining of the broken strand. These bacterial enzymes reduce the topological stress in the DNA structure by relaxing negatively, but not positively, supercoiled DNA.

oboinowl_gen:inSubset	http://purl.obolibrary.org/obo/chebi#3_STAR
oboinowl_gen:hasDbXref	MeSH:D059004
obo_purl:IAO_0000115	A topoisomerase inhibitor that inhibits the bacterial enzymes of the DNA topoisomerases, Type I class (EC 5.99.1.2) that catalyze ATP-independent breakage of one of the two strands of DNA, passage of the unbroken strand through the break, and rejoining of the broken strand. These bacterial enzymes reduce the topological stress in the DNA structure by relaxing negatively, but not positively, supercoiled DNA.
skos:notation	CHEBI:50276
oboinowl_gen:hasOBONamespace	chebi_ontology
rdf:type	http://www.w3.org/2002/07/owl#Class
oboinowl_gen:hasRelatedSynonym	EC 5.99.1.2 inhibitors topoisomerase I (EC 5.99.1.2) inhibitor DNA topoisomerase inhibitors EC 5.99.1.2 inhibitor topoisomerase I (EC 5.99.1.2) inhibitors EC 5.99.1.2 (topoisomerase I) inhibitor topoisomerase I inhibitors DNA topoisomerase inhibitor type I DNA topoisomerase inhibitor EC 5.99.1.2 (DNA topoisomerase) inhibitors EC 5.99.1.2 (topoisomerase I) inhibitors type I DNA topoisomerase inhibitors topoisomerase I inhibitor
oboinowl_gen:id	CHEBI:50276
rdfs:label	EC 5.99.1.2 (DNA topoisomerase) inhibitor
rdfs:subClassOf	http://purl.obolibrary.org/obo/CHEBI_23924

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